Detection of novel gammaherpesviruses from fruit bats in Indonesia.
Detection of novel gammaherpesviruses from fruit bats in Indonesia.
复制标题
从印度尼西亚果蝠中检测到新型伽马疱疹病毒。
DOI：
10.1099/jmm.0.000689
复制
发表时间：
2018
影响因子：
3
通讯作者：
Sawa H
中科院分区：
文献类型：
--
作者：
Wada Y;Sasaki M;Setiyono A;Handharyani E;Rahmadani I;Taha S;Adiani S;Latief M;Kholilullah ZA;Subangkit M;Kobayashi S;Nakamura I;Kimura T;Orba Y;Sawa H
蝙蝠是人畜共患病毒病原体的重要天然宿主。我们以前在印度尼西亚的果蝠中分离出一种阿尔法疱疹病毒，并在这里确定了属于疱疹病毒科其他分类群的病毒的存在。我们用泛疱疹病毒PCR方法对相同果蝠种群进行筛选，发现68个新型γ疱疹病毒序列，命名为“megabat γ疱疹病毒”（MgGHV）。对包含糖蛋白B基因和DNA聚合酶基因的约3.4 kbp连续MgGHV序列的系统发育分析显示，MgGHV序列与其他已报道的伽玛疱疹病毒序列不同。进一步分析表明，在印度尼西亚果蝠中存在疱疹病毒的共同感染。我们的发现扩展了我们对印度尼西亚蝙蝠疱疹病毒感染周期和伽玛疱疹病毒系统发育多样性的理解。
Bats are an important natural reservoir of zoonotic viral pathogens. We previously isolated an alphaherpesvirus in fruit bats in Indonesia, and here establish the presence of viruses belonging to other taxa of the familyHerpesviridae.We screened the same fruit bat population with pan-herpesvirus PCR and discovered 68 sequences of novel gammaherpesvirus, designated ‘megabat gammaherpesvirus’ (MgGHV). A phylogenetic analysis of approximately 3.4 kbp of continuous MgGHV sequences encompassing the glycoprotein B gene and DNA polymerase gene revealed that the MgGHV sequences are distinct from those of other reported gammaherpesviruses. Further analysis suggested the existence of co-infections of herpesviruses in Indonesian fruit bats. Our findings extend our understanding of the infectious cycles of herpesviruses in bats in Indonesia and the phylogenetic diversity of the gammaherpesviruses.