Tomographic mammography using a limited number of low-dose cone-beam projection images
Tomographic mammography using a limited number of low-dose cone-beam projection images
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DOI：
10.1118/1.1543934
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发表时间：
2003-03-01
期刊：
影响因子：
3.8
通讯作者：
Williams, MB
中科院分区：
文献类型：
--
作者：
Wu, T;Stewart, A;Williams, MB
描述了一种用于使用有限数量(通常为10-50张)的低剂量射线照片来重建乳房中X射线衰减的三维(3D)分布的方法。该方法使用X射线锥束成像、电子数字探测器和约束非线性迭代计算技术。重建的图像具有高分辨率的二维图像和较低分辨率的三维图像。在常规乳房X光摄影中投射到一个图像中的衰减的3D分布可以被分成多个层(通常是30-80个1毫米厚的层，取决于乳房厚度)，从而增加了在单一投影视图中经常被重叠结构遮挡的特征的显着性。研究了以非均匀角度增量、非均匀图像曝光和非均匀探测器分辨率记录乳房图像的方案，以减少获得诊断有用的3D重建所需的总X射线曝光，并提高给定曝光下的重建图像的质量。患者的总辐射剂量可以与标准双视乳房X光检查的剂量相媲美。该方法以乳房切除标本、体模和人类志愿者的图像为例进行说明。结果显示了不同的数据采集协议对图像质量的影响。(C)2003年美国医学物理学家协会。
A method is described for using a limited number (typically 10-50) of low-dose radiographs to reconstruct the three-dimensional (3D) distribution of x-ray attenuation in the breast. The method uses x-ray cone-beam imaging, an electronic digital detector, and constrained nonlinear iterative computational techniques. Images are reconstructed with high resolution in two dimensions and lower resolution in the third dimension. The 3D distribution of attenuation that is projected into one image in conventional mammography can be separated into many layers (typically 30-80 1-mm-thick layers, depending on breast thickness), increasing the conspicuity of features that are often obscured by overlapping structure in a single-projection view. Schemes that record breast images at nonuniform angular increments, nonuniform image exposure, and nonuniform detector resolution are investigated in order to reduce the total x-ray exposure necessary to obtain diagnostically useful 3D reconstructions, and to improve the quality of the reconstructed images for a given exposure. The total patient radiation dose can be comparable to that used for a standard two-view mammogram. The method is illustrated with images from mastectomy specimens, a phantom, and human volunteers. The results show how image quality is affected by various data-collection protocols. (C) 2003 American Association of Physicists in Medicine.