Assessment of Flowing Blood Coagulation Under Impact of Fibrinogen Concentration Using Optical Coherence Tomography
Assessment of Flowing Blood Coagulation Under Impact of Fibrinogen Concentration Using Optical Coherence Tomography
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DOI：
10.1109/jstqe.2015.2497328
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发表时间：
2016-05
影响因子：
4.9
通讯作者：
Xiangqun Xu;Xiangshuai Teng
中科院分区：
文献类型：
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作者：
Xiangqun Xu;Xiangshuai Teng
很少有研究表明流动血凝与纤维蛋白原浓度之间的关系。在这项研究中，我们报道了一种利用光学相干断层扫描（OCT）系统测量凝血过程中纤维蛋白原浓缩物影响下流动血液动态1/e光穿透深度（d1/e）的新方法。在不同流速下，研究了添加纤维蛋白原浓度的猪凝血在模拟血流环中的循环。在纤维蛋白原的影响下，静止血和流动血的凝血过程有显著差异。描述凝块形成各阶段光学性质变化的参数，即反应时间（tr）、凝块形成时间（tcf）和总凝块时间（tc = tr + tcf）是从d1/e随时间的变化轨迹中新得到的。红细胞压积静止血和流动血中的tr和tc分别为35%、45%和55%，与纤维蛋白原浓度成反比。更重要的是，所有纤维蛋白原浓缩物的tr和tc都随流速的增加而增加。因此，我们得出结论，d1/e-OCT是一种很有希望的工具，用于动态凝血进程和纤维蛋白原影响下静止和流动血液的状态测量。
There were few studies that demonstrate the relationship between flowing blood coagulation and fibrinogen concentration. In this study, we reported a new way of measuring dynamic 1/e light penetration depth (d1/e) of flowing blood under impact of fibrinogen concentrate during clotting by an optical coherence tomography (OCT) system. The clotting porcine blood circulated in a mock flow loop with additional fibrinogen concentrations at varying flow velocities was investigated. A significant difference of coagulation process between stationary and flowing blood under the impact of fibrinogen was observed. Parameters describing the changes in optical property at all stages of the developing clot, i.e., the reaction time (tr), clot formation time (tcf), and total clotting time (tc = tr + tcf ) were newly developed from the trace of d1/e versus time. The tr and tc were inversely proportional to the fibrinogen concentrate in both the stationary and flowing blood of hematocrit in 35%, 45%, and 55%. More importantly, the tr and tc tended to increase with the flow velocity for all the fibrinogen concentrates. Thus, we concluded that d1/e-OCT is a promisingly tool for dynamic coagulation progress and status measurements of both stationary and flowing blood under the impact of fibrinogen.