Surgical morbidity, mortality, and long-term survival in patients with peripancreatic cancer following pancreaticoduodenectomy
Surgical morbidity, mortality, and long-term survival in patients with peripancreatic cancer following pancreaticoduodenectomy
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DOI：
10.1016/s0002-9610(97)00204-3
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发表时间：
1997-12-01
影响因子：
3
通讯作者：
Lieberman, Z
中科院分区：
文献类型：
--
作者：
Stephens, J;Kuhn, J;Lieberman, Z
背景技术背景：在最近的文献中，胰腺周围癌原发肿瘤的手术切除与生存率的提高和发病率的降低有关。本综述的目的是分析结果在一个单一的institution.METHODS：在1985年和1995年之间，88例患者进行了胰头癌切除术的胰头区域和完整的长期随访。回顾患者记录，以确定发病率，死亡率和survival.RESULTS：肿瘤组织学包括胰头腺癌（n = 46），壶腹腺癌（0 = 28），十二指肠腺癌（n = 8），胆管癌（0 = 6）。26例患者（29%）发生死亡。围手术期死亡6例（7%）。在过去3年（包括33例患者）中未观察到围手术期死亡。平均随访29个月，中位生存期19个月。末次随访时，24名患者无病存活，平均生存期为43个月（1比141）。有54例患者死于癌症，平均生存21个月（1至117）。根据Kaplan和Meier统计分析，估计的2年生存率为47%，5年生存率为25%。原发肿瘤的位置（P = 0.0006）和阳性淋巴结的存在（P = 0.05）被证明有一个负面的影响survival.CONCLUSION：胰腺癌切除术可以做可接受的发病率和死亡率。这种疾病的前景仍然很差，但在一些患者中可以实现长期生存。(C)1997年，Excerpta Medica，Inc.
BACKGROUND: Surgical resection of the primary tumor in peripancreatic cancer has been associated with an improved survival and decreased morbidity in the recent literature. The purpose of this review was to analyze the results at a single institution.METHODS: Between 1985 and 1995, 88 patients underwent a pancreaticoduodenectomy for adenocarcinoma of the pancreatic head region and had complete long-term follow-up. Patient records were reviewed to determine morbidity, mortality, and survival.RESULTS: Tumor histology included pancreatic head adenocarcinoma (n = 46), ampullary adenocarcinoma (0 = 28), duodenal adenocarcinoma (n = 8), and cholangiocarcinoma (0 = 6). Morbidity occurred in 26 patients (29%). Perioperative mortality was seen in 6 patients (7%). No perioperative mortality was seen over the last 3 years, which included 33 patients. The mean follow-up was 29 months, with a median survival of 19 months. At last follow-up, 24 patients were alive without disease with an average survival of 43 months (1 to 141). There were 54 patients who died with cancer with an average survival of 21 months (1 to 117). Based on Kaplan and Meier statistical analysis the estimated survival was 47% at 2 years and 25% at 5 years. The location of the primary tumor (P = 0.0006) and the presence of positive lymph nodes (P = 0.05) was shown to have a negative impact on survival.CONCLUSION: Pancreaticoduodenectomy can be done with acceptable morbidity and mortality. The outlook with this disease remains poor, but long-term survival can be achieved in some patients. (C) 1997 by Excerpta Medica, Inc.