The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma.
The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma.
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发表时间：
2009-02
影响因子：
2
通讯作者：
T. Hidaka;S. Hama;P. Shrestha;T. Saito;Y. Kajiwara;F. Yamasaki;K. Sugiyama;K. Kurisu
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文献类型：
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作者：
T. Hidaka;S. Hama;P. Shrestha;T. Saito;Y. Kajiwara;F. Yamasaki;K. Sugiyama;K. Kurisu
细胞周期蛋白依赖性激酶（cyclin-dependent kinase，cdk）抑制剂p27的功能受细胞核（activate）和细胞质（cytosol，cytosol）之间的转位调节。没有以前的报告已经检查了胶质瘤中p27的亚细胞定位，在这里评估了高级别星形细胞瘤的预后。患者与方法采用免疫组化方法检测49例20岁以上高级别星形细胞瘤p27表达的亚细胞定位模式。统计学分析p27定位与预后的关系。结果Kaplan-Meier生存分析显示胞浆p27表达与预后差有统计学相关性（p = 0.0203），而胞核p27表达则显示预后好的趋势（p = 0.1180）。考克斯多元回归分析显示，高级别星形细胞瘤中细胞核高表达和细胞质低表达相结合的p27表达与预后显著改善相关。结论p27在高级别星形细胞瘤中胞浆低表达和胞核高表达相结合，预后较好，p27的亚细胞定位对预测高级别星形细胞瘤的预后有一定的意义。
BACKGROUND The function of the cyclin-dependent kinase (cdk) inhibitor p27 is regulated by translocation between the nucleus (activate) and the cytosol (inactivate). No previous reports have examined the subcellular localization of p27 in glioma which was evaluated here regarding the prognosis in high-grade astrocytomas. PATIENTS AND METHODS The pattern of subcellular localization of p27 expression was examined immunohistochemically in 49 patients with high-grade astrocytoma who were over 20 years of age. The relationship between p27 localization and the prognosis was statistically examined. RESULTS Kaplan-Meier survival analysis showed that cytoplasmic p27 expression was statistically associated with a worse prognosis (p = 0.0203), while nuclear p27 expression showed some tendency towards a better prognosis (p = 0.1180). Cox multiple regression analysis showed the combination of high nuclear and low cytoplasmic p27 expression associated with a significantly better prognosis in high-grade astrocytoma. CONCLUSION A combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytomas and thus the subcellular localization of p27 expression is useful for predicting the prognosis for these patients.