Rhabdomyolysis associated with acute renal failure in patients with severe acute respiratory syndrome
Rhabdomyolysis associated with acute renal failure in patients with severe acute respiratory syndrome
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DOI：
10.1111/j.1368-5031.2005.00540.x
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发表时间：
2005-10-01
影响因子：
2.6
通讯作者：
Fang, JT
中科院分区：
文献类型：
--
作者：
Chen, LL;Hsu, CW;Fang, JT
2003年台湾爆发严重急性呼吸系统综合症(SARS)。SARS合并横纹肌溶解症的报道很少。本研究报告了三例在SARS临床病程中发生的横纹肌溶解症。2003年4月4日至6月4日，30名疑似SARS患者被送往林口长庚医院隔离病房。30例患者，其中男性4例，女性26例，年龄12~87岁(平均40岁)。11例(36.7%)患者发生呼吸衰竭，需要机械通气并麻痹治疗；3例(10%)横纹肌溶解合并急性肾功能衰竭，1例接受血液透析；4例(13.3%)死亡。3例横纹肌溶解症患者均接受镇静和麻木机械通气治疗。1例患者行血液透析。两名患者死于多器官功能衰竭，一名患者从横纹肌溶解合并急性肾功能衰竭中完全康复。SARS是一种严重的呼吸道疾病，其病原学是一种新的冠状病毒。疑似SARS病毒感染所致横纹肌溶解。麻痹治疗下的制动和类固醇在横纹肌溶解症的发生中也可能很重要。
An outbreak of severe acute respiratory syndrome (SARS) occurred in Taiwan in 2003. SARS complicated with rhabdomyolysis has rarely been reported. This study reported three cases of rhabdomyolysis developing during the clinical course of SARS. Thirty probable SARS patients were admitted to the isolation wards at Linkou Chang Gung Memorial Hospital between 4 April and 4 June 2003. Thirty patients, including four men and 26 women aged from 12 to 87 years (mean age 40). Eleven (36.7%) patients had respiratory failure and required mechanical ventilation with paralytic therapy; three (10%) patients had rhabdomyolysis complicated with acute renal failure and one received haemodialysis; four (13.3%) patients died. Three cases with rhabdomyolysis all received sedative and paralytic therapy for mechanical ventilation. Haemodialysis was performed on one patient. Two patients died from multiple organ failure, and one patient fully recovered from rhabdomyolysis with acute renal failure. SARS is a serious respiratory illness, and its aetiology is a novel coronavirus. Rhabdomyolysis resulting from SARS virus infection was strongly suspected. Immobilisation under paralytic therapy and steroids may also be important in developing rhabdomyolysis.