Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.
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DOI：
10.1161/circresaha.115.306301
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发表时间：
2016-02-19
影响因子：
20.1
通讯作者：
García-Cardeña G
中科院分区：
文献类型：
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作者：
Gimbrone MA Jr;García-Cardeña G
动脉血管病变易发区的内皮衬里功能障碍是动脉粥样硬化性心血管疾病病理学的重要因素。内皮细胞功能障碍（ECD），在其最广泛的意义上，包括一系列的各种非适应性改变的功能表型，具有重要意义的止血和血栓形成的调节，局部血管紧张度和氧化还原平衡，以及协调急性和慢性炎症反应的动脉壁。在这篇综述中，我们追溯了内皮细胞功能障碍概念的演变，重点关注其在动脉粥样硬化病变发生和发展中的关键作用的细胞和分子机制的最新见解;探讨其与经典的以及最近定义的动脉粥样硬化性心血管疾病的临床危险因素的关系;考虑目前的内皮细胞功能障碍的临床评估方法;并概述了一些有希望的新方向，为它的早期发现和治疗。
Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell dysfunction (ECD), in its broadest sense, encompasses a constellation of various non-adaptive alterations in functional phenotype, which have important implications for the regulation of hemostasis and thrombosis, local vascular tone and redox balance, and the orchestration of acute and chronic inflammatory reactions within the arterial wall. In this review, we trace the evolution of the concept of endothelial cell dysfunction, focusing on recent insights into the cellular and molecular mechanisms that underlie its pivotal roles in atherosclerotic lesion initiation and progression; explore its relationship to classic, as well as more recently defined, clinical risk factors for atherosclerotic cardiovascular disease; consider current approaches to the clinical assessment of endothelial cell dysfunction; and outline some promising new directions for its early detection and treatment.