Knockdown of lncRNA MIR31HG inhibits adipocyte differentiation of human adipose-derived stem cells via histone modification of FABP4.
Knockdown of lncRNA MIR31HG inhibits adipocyte differentiation of human adipose-derived stem cells via histone modification of FABP4.
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lncRNA MIR31HG 的敲低通过 FABP4 的组蛋白修饰抑制人脂肪干细胞的脂肪细胞分化。
DOI：
10.1038/s41598-017-08131-6
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发表时间：
2017-08-14
影响因子：
4.6
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Huang Y;Jin C;Zheng Y;Li X;Zhang S;Zhang Y;Jia L;Li W
Adipogenesis plays an important role in the regulation of whole-body energy homeostasis and is inextricably related to obesity. Several studies have highlighted the relevance of microRNAs in adipocyte differentiation, but the contributions of long non-coding RNAs (lncRNAs) are still largely uncharacterized. Here, we determined that lncRNA MIR31HG is related to adipocyte lineage commitment. We demonstrated that knockdown of MIR31HG inhibited adipocyte differentiation, whereas overexpression of MIR31HG promoted adipogenesis in vitro and in vivo. Furthermore, inhibition of MIR31HG reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 (FABP4), leading to suppression of its expression and adipogenesis. These results provide new insights into the molecular mechanisms of MIR31HG in terms of adipogenesis and may have implications for obesity and associated disorders.
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影响因子：
37.3
作者：
Augoff K;McCue B;Plow EF;Sossey-Alaoui K
通讯作者：
Sossey-Alaoui K
影响因子：
3.5
作者：
Cooper DR;Carter G;Li P;Patel R;Watson JE;Patel NA
通讯作者：
Patel NA
影响因子：
6.4
作者：
Jia, Ling-Fei;Wei, Su-Bi;Yu, Guang-Yan
通讯作者：
Yu, Guang-Yan
长非编码RNA ADNCR通过靶向miR-204抑制脂肪形成分化
DOI：
10.1016/j.bbagrm.2016.05.003
发表时间：
2016-07-01
影响因子：
4.7
作者：
Li, Mingxun;Sun, Xiaomei;Chen, Hong
通讯作者：
Chen, Hong
影响因子：
64.5
作者：
Rinn, John L.;Kertesz, Michael;Chang, Howard Y.
通讯作者：
Chang, Howard Y.