Reward revaluation biases hippocampal replay content away from the preferred outcome
Reward revaluation biases hippocampal replay content away from the preferred outcome
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DOI：
10.1038/s41593-019-0464-6
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发表时间：
2019-09-01
影响因子：
25
通讯作者：
van Der Meer, Matthijs A. A.
中科院分区：
文献类型：
--
作者：
Carey, Alyssa A.;Tanaka, Youki;van Der Meer, Matthijs A. A.
啮齿动物海马体自发地产生神经活动（重放）的爆发，可以描绘奖励位置的空间轨迹，这表明在基于模型的行为控制中的作用。一个很大程度上独立的文献强调奖励重估作为这种控制的试金石，但在重估条件下海马重放的内容是未知的。我们研究了饥饿和口渴之间的动机转变后清醒重放事件的内容。在提供食物和水之间的自由选择的T型迷宫的结果，大鼠将其行为转向限制的结果，但重放内容从限制的结果转移。这种效应在每天的任务经验之前，并没有随着经验而逆转。这些结果表明，重放内容并不限于反映最近的经验或走向首选目标的轨迹，并建议在确定重放内容的动机状态的作用。
The rodent hippocampus spontaneously generates bursts of neural activity (replay) that can depict spatial trajectories to reward locations, suggesting a role in model-based behavioral control. A largely separate literature emphasizes reward revaluation as the litmus test for such control, yet the content of hippocampal replay under revaluation conditions is unknown. We examined the content of awake replay events following motivational shifts between hunger and thirst. On a T-maze offering free choice between food and water outcomes, rats shifted their behavior toward the restricted outcome, but replay content was shifted away from the restricted outcome. This effect preceded experience on the task each day and did not reverse with experience. These results demonstrate that replay content is not limited to reflecting recent experience or trajectories toward the preferred goal and suggest a role for motivational states in determining replay content.