Synthesis and Antibacterial Activities of Yanglingmycin Analogues
Synthesis and Antibacterial Activities of Yanglingmycin Analogues
复制标题
杨凌霉素类似物的合成及抗菌活性
DOI：
10.1248/cpb.c14-00578
复制
发表时间：
2015-01-01
影响因子：
1.7
通讯作者：
Zhang, Ji-Wen
中科院分区：
文献类型：
--
作者：
Li, Long-Bo;Dan, Wen-Jia;Zhang, Ji-Wen
报道了杨凌霉素及其对映体以及18个杨凌霉素类似物的合成。其结构主要通过对核磁共振波谱数据的分析得到确证。抗菌活性测定表明，杨凌霉素及其部分类似物对两种重要的农业病原菌青枯雷尔氏菌和丁香假单胞菌具有显著的抑菌活性。对猕猴桃的最小抑菌浓度(MIC)为3.91~15.62微克/毫升。杨凌霉素及其类似物具有良好的抗菌活性，有望开发新型杀菌剂化合物。
The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 mu g/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.