Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study
Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study
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2 型糖尿病风险与血脂水平相关：中国农村队列研究
DOI：
10.1016/j.diabres.2017.11.011
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发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Hu, Dongsheng
中科院分区：
文献类型：
--
作者：
Zhang, Ming;Zhou, Junmei;Hu, Dongsheng
目的：目的：探讨中国农村人群2型糖尿病（T2 DM）危险性与血脂水平的关系。方法：将各血脂变量按临床分界点分为四分位数，并进行二分。采用考克斯比例风险模型估计血脂水平与T2 DM风险的风险比（HR）和95%可信区间（CI），并探讨血脂水平与其他危险因素之间的相互作用。我们在70，720.84人-年的随访中记录了720例T2 DM事件病例，发病率为10.18/1，000人-年。在多变量校正模型中，总胆固醇（TC）和甘油三酯（TG）水平以及TC/高密度脂蛋白胆固醇（HDL-C）和TG/HDL-C比值的最高四分位数与最低四分位数相比，T2 DM风险增加。例如，第四个四分位数的HR（95% CI）分别为1.34（1.03-1.74）、2.32（1.73-3.13）、1.66（1.23-2.25）和1.84（1.38-2.45）。此外，根据临床临界值，高TG水平和TC/HDL-C和TG/HDL-C比值会增加T2 DM的风险。HR（95% CI）分别为1.50（1.25-1.80）、1.24（1.03-1.48）和1.44（1.18-1.75）。2型糖尿病的风险与所有血脂变量与年龄和BMI之间的相互作用相关。结论：在中国农村人群中，血清TC、TG、TC/HDL-C、TG/HDL-C比值升高，且TC、TG、TC/HDL-C、TG/HDL-C比值与年龄、BMI之间存在交互作用，可增加T2 DM的危险性。(C)2017爱思唯尔B. V.保留所有权利。
Aim: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese.Methods: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors.Results: 11,929 participants were included in the analysis. We documented 720 incident cases of T2DM over 70,720.84 person-years of follow-up, for an incidence of 10.18/1,000 person-years. In the multivariable-adjusted model, risk of T2DM was increased with the highest versus lowest quartiles of total cholesterol (TC) and triglycerides (TG) levels and TC/high-density lipoprotein-cholesterol (HDL-C) and TG/HDL-C ratios. The HRs (95% CIs) for the fourth quartiles, for example, were 1.34 (1.03-1.74), 2.32 (1.73-3.13), 1.66 (1.23-2.25), and 1.84 (1.38-2.45), respectively. In addition, risk of T2DM was increased with high TG level and TC/HDL-C and TG/HDL-C ratios by clinical cutoffs. The HRs (95% CIs) were 1.50 (1.25-1.80), 1.24 (1.03-1.48), and 1.44 (1.18-1.75), respectively. Risk of T2DM was associated with interactions between all lipid variables and age and BMI. TG level and TG/HDL-C ratio additionally interacted with gender (all P-interaction < 0.0001).Conclusions: Risk of T2DM was increased with elevated serum levels of TC and TG and TC/HDL-C and TG/HDL-C ratios and also with interactions between high TC and TG levels and TC/HDL-C and TG/HDL-C ratios and age and BMI in a rural Chinese population. (C) 2017 Elsevier B.V. All rights reserved.