Cross-sectional and longitudinal associations of family income-to-needs ratio with cortical and subcortical brain volume in adolescent boys and girls.
Cross-sectional and longitudinal associations of family income-to-needs ratio with cortical and subcortical brain volume in adolescent boys and girls.
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DOI：
10.1016/j.dcn.2020.100796
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发表时间：
2020-08
影响因子：
4.7
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
King LS;Dennis EL;Humphreys KL;Thompson PM;Gotlib IH
性别特有的SES与神经发育的关联可能出现在青春期。我们使用全脑方法来检查灰质和白质的体积。性与SES的相互作用解释了青春期体积的变化。性别是分析SES和脑容量时要考虑的一个重要变量。神经发育方面的偏差可能是儿童较低的社会经济地位与认知和社会情感领域的困难之间的联系的基础。以前大多数关于儿童社会经济地位和大脑形态之间关系的研究都使用了横断面设计，样本跨越了广泛的年龄范围，遮盖了青春期特有的影响。社会经济地位和神经发育之间的性别差异可能在青春期出现或加剧。在旧金山湾区的一个样本中，我们使用基于全脑张量的形态计量学来检验青春期早期(9-13岁；N=147)家庭收入需求比(INR)与皮质和皮质下灰质和白质体积变化之间的横截面关联的性别差异，以及从青春期早期到晚期(11-16岁，N=109)INR与体积变化之间的纵向关联。生物性行为与INR相互作用，从横向和纵向上解释了几个区域的体积变化。影响主要发生在皮质灰质区，包括联合皮质和感觉运动加工区。男孩的效应大小往往比女孩的大。在分析家庭收入对青春期结构性神经发育的影响时，生物性别可能是一个重要的变量。
Sex-specific associations of SES with neurodevelopment may emerge in adolescence. We used a whole-brain approach to examine gray and white matter volume. Sex interacted with SES to explain variation in volume across adolescence. Sex is an important variable to consider in analyses of SES and brain volume. Deviations in neurodevelopment may underlie the association between lower childhood socioeconomic status and difficulties in cognitive and socioemotional domains. Most previous investigations of the association between childhood socioeconomic status and brain morphology have used cross-sectional designs with samples that span wide age ranges, occluding effects specific to adolescence. Sex differences in the association between socioeconomic status and neurodevelopment may emerge or intensify during adolescence. In a sample representative of the San Francisco Bay Area, we used whole-brain tensor-based morphometry to examine sex differences in the cross-sectional association between variation in family income-to-needs ratio (INR) and cortical and subcortical gray and white matter volume during early adolescence (ages 9–13 years; N = 147), as well as in the longitudinal association between INR and change in volume from early to later adolescence (ages 11–16 years, N = 109). Biological sex interacted with INR to explain variation in volume in several areas cross-sectionally and longitudinally. Effects were primarily in cortical gray matter areas, including regions of the association cortex and sensorimotor processing areas. Effect sizes tended to be larger in boys than in girls. Biological sex may be an important variable to consider in analyses of the effects of family income on structural neurodevelopment during adolescence.
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影响因子：
7.6
作者：
Humphreys, Kathryn L.;Kircanski, Katharina;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
影响因子：
3.7
作者：
Brito NH;Noble KG;Pediatric Imaging, Neurocognition, Genetics Study
通讯作者：
Pediatric Imaging, Neurocognition, Genetics Study
影响因子：
7.6
作者：
Joel, Daphna;McCarthy, Margaret M.
通讯作者：
McCarthy, Margaret M.
影响因子：
6.3
作者：
Amone-P'Olak, K.;Burger, H.;Ormel, J.
通讯作者：
Ormel, J.
影响因子：
3.7
作者：
Fernald A;Marchman VA;Weisleder A
通讯作者：
Weisleder A