Vision using multiple distinct rod opsins in deep-sea fishes
Vision using multiple distinct rod opsins in deep-sea fishes
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DOI：
10.1126/science.aav4632
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发表时间：
2019-05-10
期刊：
影响因子：
56.9
通讯作者：
Salzburger, Walter
中科院分区：
文献类型：
--
作者：
Musilova, Zuzana;Cortesi, Fabio;Salzburger, Walter
脊椎动物的视觉是通过与发色团结合的视蛋白组成的感光色素来完成的。在昏暗的光线下，脊椎动物通常依靠单一视蛋白杆状视蛋白[rhodopsin 1 (RH1)]获取视觉信息。通过检查101种鱼类的基因组，我们发现三个深海硬骨鱼谱系独立地扩展了它们的RH1基因库。其中，银鳍（Diretmus argenteus）在脊椎动物中拥有最多的视蛋白（2个视锥蛋白和38个视杆蛋白）。长鳍鱼表达多达14种rh1（包括已知的最蓝移杆状光色素），覆盖了深海中剩余日光和生物发光光谱的范围。我们的发现为脊椎动物多视杆蛋白视觉的反复进化提供了分子和功能证据。
Vertebrate vision is accomplished through light-sensitive photopigments consisting of an opsin protein bound to a chromophore. In dim light, vertebrates generally rely on a single rod opsin [rhodopsin 1 (RH1)] for obtaining visual information. By inspecting 101 fish genomes, we found that three deep-sea teleost lineages have independently expanded their RH1 gene repertoires. Among these, the silver spinyfin (Diretmus argenteus) stands out as having the highest number of visual opsins in vertebrates (two cone opsins and 38 rod opsins). Spinyfins express up to 14 RH1s (including the most blueshifted rod photopigments known), which cover the range of the residual daylight as well as the bioluminescence spectrum present in the deep sea. Our findings present molecular and functional evidence for the recurrent evolution of multiple rod opsin-based vision in vertebrates.