Aza-BODIPY based probe for photoacoustic imaging of ONOO- in vivo
Aza-BODIPY based probe for photoacoustic imaging of ONOO- in vivo
复制标题
基于 Aza-BODIPY 的探针，用于 ONOO™ 体内光声成像
DOI：
10.1016/j.cclet.2021.05.048
复制
发表时间：
2021-12-01
影响因子：
9.1
通讯作者：
Zhou, Xin
中科院分区：
文献类型：
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作者：
Ma, Danghui;Hou, Shumin;Zhou, Xin
有效地检测体内ONOO-变异对于理解复杂的病理生理过程具有重要意义。本文报道了一种用于ONOO-活体成像的光声探针AZB-1。AZB-1在660 nm处显示出最初很强的光声信号。通过关闭aza-BODIPY核2-位共轭吸电子基团引起的ICT效应，可以关闭其PA信号。此外，该探针被成功地用于成像炎症小鼠模型中的ONOO-变异。合理利用这一策略可以为制备新型PA化学传感器提供有力的平台。(C)2021由Elsevier B. V.代表中国化学会和中国医学科学院药物研究所出版。
The effective detecting ONOO- variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic (PA) probe AZB-1 for imaging ONOO- in vivo. AZB-1 showed an originally strong photoacoustic signal at 660 nm. And its PA signal can be turned offby shutting the ICT effect caused by the conjugated electron withdrawing group at 2-position of the aza-BODIPY core. Moreover, the probe was successfully employed to imaging ONOO- variations in inflammatory mice models. Wisely utilized this strategy may serve as powerful platforms for the preparation of novel PA chemosensors. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.