Lifetime Prevalence of Mood and Anxiety Disorders in Fragile X Premutation Carriers
Lifetime Prevalence of Mood and Anxiety Disorders in Fragile X Premutation Carriers
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DOI：
10.4088/jcp.09m05407blu
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发表时间：
2011-02-01
影响因子：
5.3
通讯作者：
Hagerman, Randi J.
中科院分区：
文献类型：
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作者：
Bourgeois, James A.;Seritan, Andreea L.;Hagerman, Randi J.
目的：作者研究了DSM-IV-TR中脆性X基因前置突变成人人群中精神疾病的终生患病率。方法：2007-2008年，对85例脆性X前兆突变患者、47例脆性X相关震颤/共济失调综合征（FXTAS）患者（男性33例，女性14例，平均年龄66岁）和38例无FXTAS患者（男性16例，女性22例，平均年龄52岁）进行DSM-IV结构化临床访谈。在有和没有FXTAS的携带者中，情绪和焦虑障碍的终生患病率与来自国家共病调查复制（NCS-R）的现有年龄特定人群估计值进行了比较。结果：在FXTAS患者中，30人（65%）符合DSM-IV-TR心境障碍的终身标准；24例（52%）符合DSM-IV-TR焦虑症的终生标准。在非fxtas参与者中，有15例终身情绪障碍（42%）和18例终身焦虑障碍（47%）。当与特定年龄的NCS-R数据进行比较时，任何情绪障碍的终生患病率(P
Objective: The authors studied the lifetime prevalence of DSM-IV-TR psychiatric disorders in a population of adults with the fragile X premutation.Method: The Structured Clinical Interview for DSM-IV was conducted, from 2007-2008, in 85 individuals with the fragile X premutation, 47 with the fragile X-associated tremor/ataxia syndrome (FXTAS; 33 male, 14 female; mean age = 66 years) and 38 without FXTAS (16 male, 22 female; mean age = 52 years). Lifetime prevalence for mood and anxiety disorders among carriers with and without FXTAS was compared to available age-specific population estimates from the National Comorbidity Survey Replication (NCS-R).Results: Among participants with FXTAS, 30 (65%) met lifetime DSM-IV-TR criteria for a mood disorder; 24 (52%) met lifetime DSM-IV-TR criteria for an anxiety disorder. Among the non-FXTAS participants, there were 15 instances of lifetime mood disorder (42%) and 18 of lifetime anxiety disorder (47%). When compared to age-specific NCS-R data, the lifetime prevalences of any mood disorder (P