Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis.
Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis.
复制标题
载脂蛋白 M T-778C 多态性与中国人群的血脂水平和冠心病风险相关：一项荟萃分析。
DOI：
10.1186/1476-511x-12-135
复制
发表时间：
2013-09-16
影响因子：
4.5
通讯作者：
Yin RX
中科院分区：
文献类型：
--
作者：
Zhang Z;Chu G;Yin RX
载脂蛋白M（APOM）T-778 C基因多态性与血脂水平和冠心病（CAD）风险相关，但结果不确定。本研究旨在探讨中国人群中APOM T-778 C多态性与血脂水平和冠心病风险之间的关系。检索MEDLINE、EMBASE、科克伦图书馆和中国期刊全文数据库。使用标准化方法提取数据。通过平均差（MD）和95%置信区间（CI）或比值比（OR）和95% CI评估相关性。本荟萃分析纳入了10项研究（4，413例患者）。合并效应表明，CT+CC组的总胆固醇（TC）（MD：-0.36，95%CI：-0.53 --0.19，P < 0.0001）和低密度脂蛋白胆固醇（LDL-C）（MD：-0.08，95%CI：-0.16 --0.01，P = 0.03）水平高于TT组。TT组和CT+CC组的甘油三酯（MD：0.06，95%CI：-0.04 ~0.15，P = 0.22）和高密度脂蛋白胆固醇（MD：0.00，95%CI：-0.03-0.03，P = 0.93）水平无差异。合并效应显示，冠心病组CT+CC基因型频率高于对照组（OR：1.97，95% CI：1.62-2.39，P < 0.00001;异质性检验x2 = 2.96，P = 0.71，I2 = 0%）。当前荟萃分析的结果显示，CT+CC组的TC和LDL-C水平高于TT组。在中国人群中，APOM T-778 C基因多态性与冠心病的发病风险显著相关，CT+CC基因型与冠心病的发病风险增加相关。
The apolipoprotein M (APOM) T-778C gene polymorphism has been associated with serum lipid levels and the risk of coronary artery disease (CAD), but the results are inconclusive. The purpose of this meta-analysis was to detect the association between the APOM T-778C polymorphism and serum lipid levels and the risk of CAD in the Chinese population. Databases of MEDLINE, EMBASE, the Cochrane Library and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by mean difference (MD) with 95% confidence intervals (CI) or odds ratio (OR) with 95% CI. Ten studies with 4,413 patients were included in this meta-analysis. Pooled effects indicated that CT+CC group had higher levels of total cholesterol (TC) (MD:-0.36, 95% CI: -0.53 – -0.19, P < 0.0001) and low-density lipoprotein cholesterol (LDL-C) (MD: -0.08, 95% CI: -0.16 – -0.01, P = 0.03) than TT group. There was no difference in the levels of triglyceride (MD: 0.06, 95% CI: -0.04 – 0.15, P = 0.22) and high-density lipoprotein cholesterol (MD: 0.00, 95% CI: -0.03–0.03, P = 0.93) between TT and CT+CC groups. Pooled effects showed that CAD group had higher CT+CC genotype frequency than control group (OR: 1.97, 95% CI: 1.62–2.39, P < 0.00001; heterogeneity test x2 = 2.96, P = 0.71, I2 = 0%). The results of the current meta-analysis show that the CT+CC group has higher levels of TC and LDL-C than the TT group. Moreover, there is also a prominent association between APOM T-778C polymorphism and the risk of CAD in the Chinese population, the CT+CC genotype is associated with increased risk of CAD.