The Deep Homology of the Autopod: Insights from Hox Gene Regulation
The Deep Homology of the Autopod: Insights from Hox Gene Regulation
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DOI：
10.1093/icb/ict029
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发表时间：
2013-08-01
影响因子：
2.6
通讯作者：
Davis, Marcus C.
中科院分区：
文献类型：
--
作者：
Davis, Marcus C.
从鱼鳍进化出四足动物的四肢是一个重要的功能和形态转变，但就潜在的遗传机制而言，它有多重要？化石记录提供了对形态变化的深入了解。然而，为了理解潜在的机制，我们必须深入研究活脊椎动物的基因调控网络。HoxA/D的表达在一个基础的actinopterygian，北美白鲟，Polyodon spathula的分析，揭示了表达模式长期以来被认为是一个独特的发展签名的autopod（手/脚，数字），并显示在四足动物控制的“数字增强器”的监管景观。这些数据，沿着最近的种间转基因实验，从软骨鱼类的表达结果，并从化石的数据支持的概念，即直足类股与其他gnathostomes的鳍（远端桡骨）的远端内骨骼的深同源性。
The evolution of tetrapod limbs from fish fins was a significant functional and morphological shift, but how significant was it in terms of the underlying genetic mechanisms? The fossil record provides insight into the morphological changes. However, to understand the underlying mechanisms, we must peer into the gene regulatory networks of living vertebrates. Analysis of HoxA/D expression in a basal actinopterygian, the North American paddlefish, Polyodon spathula, reveals patterns of expression long considered to be a unique developmental signature of the autopod (hands/feet, digits) and shown in tetrapods to be controlled by a "digit enhancer" regulatory landscape. These data, along with recent interspecific transgenic experiments, expression results from chondrichthyans, and data from fossils support the notion that the autopod shares a deep homology with the distal endoskeleton of the fin (distal radials) of other gnathostomes.