Obstructive sleep apnea characteristics in patients with well-controlled acromegaly and their compliance with positive airway pressure therapy
Obstructive sleep apnea characteristics in patients with well-controlled acromegaly and their compliance with positive airway pressure therapy
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DOI：
10.3906/sag-1612-139
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发表时间：
2017-01-01
影响因子：
2.3
通讯作者：
Saygili, Fusun
中科院分区：
文献类型：
--
作者：
Tasbakan, Mehmet Sezai;Kacmaz Basoglu, Ozen;Saygili, Fusun
背景/目的：肢端肥大症通常与阻塞性睡眠呼吸暂停综合征 (OSAS) 相关，发生率在 40% 至 80% 之间。本研究的目的是评估患有睡眠呼吸暂停症状的肢端肥大症患者的临床和多导睡眠图特征，并确定患有 OSAS 诊断的肢端肥大症患者的气道正压通气 (PAP) 依从性。 材料和方法：本前瞻性研究纳入了 28 名控制良好的患有睡眠呼吸暂停症状的肢端肥大症患者（17 名男性，平均年龄 48.7 +/- 10.1 岁）。对人口统计数据、人体测量数据和病史进行了评估。在实验室进行整夜多导睡眠监测。结果：多导睡眠监测结果显示，25 名患者 (89.3%) 患有 OSAS，平均呼吸暂停低通气指数 (AHI) 为 37.7 +/- 28.8/h。所有 17 名男性患者均诊断为 OSAS，而 8 名女性患者 (72.7%) 患有 OSAS (P = 0.05)。男性患者也比女性患者有更严重的 OSAS（AHI 分别为 48.3 +/- 29.0 和 21.3 +/- 20.1 事件/小时；P = 0.012）。 28 名患者中有 22 名被认为是 PAP 治疗的合格候选人。随访期间发现 PAP 依从率为 50%。结论：我们的结果证实 OSAS 是肢端肥大症患者的常见疾病，并且大多数患者需要 PAP 治疗。因此，所有肢端肥大症患者都应根据 OSAS 进行评估，并密切随访以评估 PAP 依从性。
Background/aim: Acromegaly is often associated with obstructive sleep apnea syndrome (OSAS) with a frequency between 40% and 80%. The aim of the present study was to evaluate the clinical and polysomnographic characteristics of acromegaly patients with sleep apnea symptoms and to identify positive airway pressure (PAP) adherence in acromegaly patients with OSAS diagnosis.Materials and methods: Twenty-eight well-controlled acromegaly patients (17 males, mean age 48.7 +/- 10.1 years) with sleep apnea symptoms were included in this prospective study. Demographic data, anthropometric measurements, and medical history were evaluated. Full-night in-laboratory polysomnography was performed.Results: Polysomnography results showed that 25 patients (89.3%) had OSAS with a mean apnea-hypopnea index (AHI) of 37.7 +/- 28.8/h. All 17 male patients were diagnosed with OSAS, whereas 8 female patients (72.7%) had OSAS (P = 0.05). Male patients also had more severe OSAS than females (AHI 48.3 +/- 29.0 vs. 21.3 +/- 20.1 events/h, respectively; P = 0.012). Twenty-two patients out of 28 were considered to be eligible candidates for PAP therapy. The PAP adherence rate was found to be 50% during follow-up.Conclusion: Our results confirm OSAS as a common disorder in acromegaly patients as well as PAP therapy being required for a majority of patients. Therefore, all acromegaly patients should be assessed in terms of OSAS and be followed closely for the evaluation of PAP adherence.