Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?
Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?
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DOI：
10.1371/journal.pbio.1002380
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发表时间：
2016-03
期刊：
影响因子：
9.8
通讯作者：
Qi G
中科院分区：
文献类型：
--
作者：
Hemingway J;Shretta R;Wells TN;Bell D;Djimdé AA;Achee N;Qi G
过去十年在疟疾控制方面取得的进展促使关于消除和根除疟疾的全球对话日益增多。疟疾产品开发渠道从未如此强大，有希望发现、治疗和预防疟疾的新工具，包括创新诊断、药物、疫苗、病媒控制产品以及改进的监测和应对机制。全球疟疾疫苗管道中至少有25个项目，以及47种药物和13种病媒控制产品。此外，目前有几种下一代诊断工具和参考方法正在开发中，其中许多预计将在未来十年内推出。开发和采用这些工具，辅以确保目标人群迅速接受的战略，加强信息管理、监测和应对机制，以及持续的财政和政治承诺，对于实现全球根除至关重要。如果没有新的疫苗、药物和病媒控制产品，在许多情况下就不可能消除疟疾。虽然在过去十年中，在每个这些领域都开发了健康的新产品管道，但要将这些产品推向市场并为其使用部署最佳战略，还需要做大量工作。
Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and prevent malaria, including innovative diagnostics, medicines, vaccines, vector control products, and improved mechanisms for surveillance and response. There are at least 25 projects in the global malaria vaccine pipeline, as well as 47 medicines and 13 vector control products. In addition, there are several next-generation diagnostic tools and reference methods currently in development, with many expected to be introduced in the next decade. The development and adoption of these tools, bolstered by strategies that ensure rapid uptake in target populations, intensified mechanisms for information management, surveillance, and response, and continued financial and political commitment are all essential to achieving global eradication. Malaria elimination in many settings will not be possible without new vaccines, drugs, and vector control products. Although a healthy pipeline of new products in each of these areas has been developed over the past decade, significant work is required to bring these products to market and deploy optimal strategies for their use.