New destruxins from the marine-derived fungus Beauveria felina
New destruxins from the marine-derived fungus Beauveria felina
复制标题
DOI：
10.1038/ja.2006.76
复制
发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Berlinck, Roberto G. S.
中科院分区：
文献类型：
--
作者：
Lira, Simone P.;Vita-Marques, Aline M.;Berlinck, Roberto G. S.
从海洋来源的真菌Beauveria felina的生长培养基中获得的细胞毒性和抗结核活性丁酮提取物的化学研究导致分离出两种新的破坏菌素，[P-MePro]破坏菌素E氯乙醇（1）和假破坏菌素C（3），沿着五种已知的环状缩酚酸肽。通过光谱数据分析确定了新的destruxin衍生物的结构，而通过Marveland分析确定了常见氨基酸残基的绝对构型。I中2（R），4（S）-5-氯-2，4-二羟基戊酸残基的绝对构型可以通过应用J-基构型方法，然后用R-MPA-Cl衍生化和NMR分析来确定。
Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [P-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(R),4(S)-5-chloro-2,4-dihydroxypentanoic acid residue in I could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis.