Diffusion-weighted imaging of the fetal brain in vivo
Diffusion-weighted imaging of the fetal brain in vivo
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DOI：
10.1002/mrm.21459
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Glenn, Orit A.
中科院分区：
文献类型：
--
作者：
Kim, Dong-Hyun;Chung, SungWon;Glenn, Orit A.
提出了一种在子宫内对胎儿脑进行弥散加权成像（DWI）和弥散张量成像（DTI）的方法。在子宫内进行弥散成像的主要困难是运动的存在。通过修改传统的单次激发自旋回波平面DWI与一个短的重复时间序列，序列，执行DWI和DTI的母亲（13秒和18秒，分别）屏气设计。T，使用短重复时间引起的加权通过散布具有附加B=0图像采集的扩散成像来补偿。在宫内胎儿脑DWI和DTI使用该序列进行。定量分析显示，使用该序列时，获得的表观扩散系数（ADC;定向平均ADC）值差异极小。该方法可以很容易地在临床环境中实施，并且在扫描不能忍受更长时间屏气的母亲时特别有用。
A method of performing diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) of the fetal brain in utero is proposed. The major difficulty of performing diffusion imaging in utero is the presence of motion. By modifying conventional single-shot spin-echo echo-planar DWI with a short repetition time sequence, a sequence that performs DWI and DTI within a breath-hold of the mother (13 sec and 18 sec, respectively) was devised. T, weighting caused by the use of short repetition times is compensated by interspersing diffusion imaging with additional b=0 image acquisitions. In utero fetal brain DWI and DTI were performed using this sequence. Quantitative analysis revealed minimal differences in the obtained apparent diffusion coefficient (ADC; directionally averaged ADC) values when using this sequence. The method can be readily implemented in a clinical setting and is especially useful when scanning mothers who cannot tolerate lengthier breath-holds.