Mediator release after nasal airway challenge with allergen.
Mediator release after nasal airway challenge with allergen.
复制标题
过敏原刺激鼻气道后介质释放。
DOI：
10.1164/arrd.1983.128.4.597
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Lichtenstein,LM
中科院分区：
文献类型：
--
作者：
Naclerio,RM;Meier,HL;Kagey-Sobotka,A;AdkinsonJr,NF;Meyers,DA;Norman,PS;Lichtenstein,LM
人类过敏性疾病的Anin vivomodel已经被开发出来，其中用抗原进行鼻攻击导致生理变化，连同增加量的炎性介质释放到通过用盐水洗鼻获得的鼻分泌物中。在涉及35名受试者的105项实验中，只有过敏受试者始终表现出肥大细胞介质、组胺和推定的肥大细胞介质、TAME-酯酶和PGD 2的浓度增加。每种介质的释放与生理变化（打喷嚏）显著相关（p < 0.001）。每种介质的释放也与其他2种介质的释放显著相关（p < 0.001）。该系统，第一次，清楚地涉及体内症状和介质释放，因此应提供一个很好的工具，为进一步研究过敏反应和鼻病理生理学。
Anin vivomodel of human allergic disease has been developed in which nasal challenge with antigen leads to physiologic changes, together with a release of increased amounts of inflammatory mediators into nasal secretions obtained by washing the nose with saline. In 105 experiments involving 35 subjects, only allergic subjects consistently demonstrated an increase in the concentrations of the mast cell mediator, histamine, and the putative mast cell mediators, TAME-esterase and PGD2. The release of each mediator was significantly (p < 0.001) related to the physiologic change (sneezing). The release of each mediator also correlated significantly with the release of the other 2 mediators (p < 0.001). This system, for the first time, clearly relates anin vivosymptom and mediator release and thus should provide an excellent tool for the further study of the allergic response and nasal pathophysiology.