Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea
Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea
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DOI：
10.1086/525047
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发表时间：
2008-02-01
影响因子：
6.4
通讯作者：
Young, Vincent B.
中科院分区：
文献类型：
--
作者：
Chang, Ju Young;Antonopoulos, Dionysios A.;Young, Vincent B.
由艰难梭菌（CDAD）引起的抗生素相关性腹泻被认为反映了病原体破坏的微生物群落的定殖。我们通过对16 S rRNA编码基因序列进行非培养系统发育分析，分析了CDAD患者（初次发作和复发）的粪便微生物群。与对照组和首次发病患者相比，复发性CDAD患者的粪便群落在细菌组成方面具有高度可变性，其特征在于多样性显著降低。微生物多样性的保存和恢复可能代表预防和治疗复发性CDAD的新策略，这通常是现有疗法的障碍。
Antibiotic-associated diarrhea due to Clostridium difficile (CDAD) is thought to reflect colonization of a disrupted microbial community by the pathogen. We profiled the fecal microbiota of patients with CDAD (both initial and recurrent episodes) by culture-independent phylogenetic analysis of 16S rRNA-encoding gene sequences. Compared with those from control subjects and patients with an initial episode, the fecal communities in patients with recurrent CDAD were highly variable in bacterial composition and were characterized by markedly decreased diversity. Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies.