ANXIOLYTIC AND ANXIOGENIC DRUG EFFECTS ON EXPLORATORY ACTIVITY IN AN ELEVATED PLUS-MAZE - A NOVEL TEST OF ANXIETY IN THE RAT
ANXIOLYTIC AND ANXIOGENIC DRUG EFFECTS ON EXPLORATORY ACTIVITY IN AN ELEVATED PLUS-MAZE - A NOVEL TEST OF ANXIETY IN THE RAT
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DOI：
10.1016/0091-3057(86)90552-6
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发表时间：
1986-03-01
影响因子：
3.6
通讯作者：
FILE, SE
中科院分区：
文献类型：
--
作者：
PELLOW, S;FILE, SE
目前的研究进一步研究了新型假定的抗焦虑和致焦虑化合物在焦虑动物模型中的作用，据信这些化合物通过作用于 GABA-苯二氮卓受体复合物来诱导其作用。预计该结果还将进一步验证基于大鼠高架十字迷宫中开臂与闭臂条目比率的新型焦虑测试。新型抗焦虑药 CL 218,872 (10-20 mg/kg) 和曲卡唑酯 (5 mg/kg) 显着增加了在高架十字迷宫的开放臂上花费的时间百分比，这与它们在其他几项动物试验中的抗焦虑活性一致。与其他动物试验的结果一致，苯喹啉 PK 8165 (10-25 mg/kg)、3,4-苯二氮卓托非索泮 (25-50 mg/kg) 或丁螺环酮 (0.5-20 mg/kg) 没有观察到抗焦虑活性。苯二氮卓受体反向激动剂 FG 7142 (1-5 mg/kg) 和 CGS 8216 (3-10 mg/kg) 在此测试中具有致焦虑活性，非典型苯二氮卓 Ro 5-4864 (1-5 mg/kg) 也具有致焦虑活性。然而有趣的是，苯二氮卓受体拮抗剂Ro 15-1788 (10-20 mg/kg)和Zk 93426 (5-10 mg/kg)在该测试中没有致焦虑活性。
The current studies further investigated the effects, in animal models of anxiety, of novel putative anxiolytic and anxiogenic compounds believed to induce their effects by actions at the GABA-benzodiazepine receptor complex. It was expected that the results would also provide further validation for a novel test of anxiety based on the ratio of open to closed arm entries in an elevated plus maze in the rat. The novel putative anxiolytics CL 218,872 (10-20 mg/kg) and tracazolate (5 mg/kg) significantly elevated the percentage of time spent on the open arms of an elevated plus-maze, consistent with their anxiolytic activity in several other animal tests. Also consistent with results from other animal tests, no anxiolytic activity was observed for the phenylquinoline PK 8165 (10-25 mg/kg), the 3,4-benzodiazepine tofisopam (25-50 mg/kg), or buspirone (0.5-20 mg/kg). The benzodiazepine receptor inverse agonists FG 7142 (1-5 mg/kg) and CGS 8216 (3-10 mg/kg) had anxiogenic activity in this test, as did the atypical benzodiazepine Ro 5-4864 (1-5 mg/kg). Interestingly, however, the benzodiazepine receptor antagonists Ro 15-1788 (10-20 mg/kg) and Zk 93426 (5-10 mg/kg) had no anxiogenic activity in this test.