Heat shock cognate 70 mutations in sporadic breast carcinoma.
Heat shock cognate 70 mutations in sporadic breast carcinoma.
复制标题
DOI：
--
复制
发表时间：
1999-09
期刊：
影响因子：
11.2
通讯作者：
C. Bakkenist;J. Koreth;Cory SM Williams;N. Hunt;J. McGee
中科院分区：
文献类型：
--
作者：
C. Bakkenist;J. Koreth;Cory SM Williams;N. Hunt;J. McGee
热休克同源蛋白70（HSC 70）是一种组成型表达的分子伴侣，其功能是调节细胞蛋白质的结构、亚细胞定位和周转。它也是中心体的一个组成部分，在有丝分裂/减数分裂纺锤体形成和细胞质微管组织过程中促进重排。我们将HSC 70定位于11q23.3，这是一个在40%的散发性乳腺癌和其他癌症中缺失的区域。测序结果显示，在15例散发性乳腺癌中，有2例HSC 70的NH 2-末端ATP酶结构域发生突变。在这两种情况下，突变是一致的等位基因的不平衡，表明HSC 70是一个目标的体细胞突变和缺失的一部分乳腺癌。
Heat Shock Cognate 70 (HSC70) is a constitutively expressed molecular chaperone, functions of which regulate the structure, subcellular localization, and turnover of cell proteins. It is also a component of the centrosome facilitating rearrangements during mitotic/meiotic spindle formation and cytoplasmic microtubule organization. We localized HSC70 to 11q23.3, a region deleted in 40% of sporadic breast and other cancers. Sequencing demonstrated mutation in the NH2-terminal ATPase domain of HSC70 in 2 of 15 sporadic breast carcinomas examined. In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.