Intranasal oxytocin reduces social perception in women: Neural activation and individual variation
Intranasal oxytocin reduces social perception in women: Neural activation and individual variation
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DOI：
10.1016/j.neuroimage.2016.12.046
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发表时间：
2017-02-15
期刊：
影响因子：
5.7
通讯作者：
King, Tricia Z.
中科院分区：
文献类型：
--
作者：
Hecht, Erin E.;Robins, Diana L.;King, Tricia Z.
迄今为止，大多数鼻内催产素研究都是在男性中进行的，但最近的研究表明，女性的反应可能与男性有很大不同。这项随机、双盲、安慰剂对照的研究涉及28名未使用激素避孕的女性样本。参与者观看几何形状的动画，这些动画描绘了随机运动或社交互动，如玩耍、追逐或打架。探究式问题询问是否有任何形状是“朋友”或“不是朋友”。社交视频之前有社交关系或体型变化的提示。所有受试者在扫描1时接受鼻内安慰剂喷雾剂。在扫描1时，实验者并没有对鼻腔喷雾剂的内容视而不见，但参与者却视而不见。扫描2采用随机双盲设计。在第2次扫描中，一半接受了第二剂安慰剂，另一半接受了24iii次鼻内催产素。我们在基线上测量了神经对这些动画的反应，以及催产素引起的神经活动的变化。催产素减少了早期视觉皮层和背流运动处理区域的激活，从而减少了社交>大小的对比，表明与社交注意力相关的活动减少。催产素也减少了对形状是“朋友”或“不是朋友”的认可，这与神经激活的减少显著相关。此外，在基线时感知到较少社会关系的参与者更有可能在涉及社会感知和社会认知的广泛区域网络中表现出催产素引起的增加，这表明基线时较低的社会加工可能预示着对催产素的更积极的神经反应。
Most intranasal oxytocin research to date has been carried out in men, but recent studies indicate that females' responses can differ substantially from males'. This randomized, double-blind, placebo-controlled study involved an all-female sample of 28 women not using hormonal contraception. Participants viewed animations of geometric shapes depicting either random movement or social interactions such as playing, chasing, or fighting. Probe questions asked whether any shapes were "friends" or "not friends." Social videos were preceded by cues to attend to either social relationships or physical size changes. All subjects received intranasal placebo spray at scan 1. While the experimenter was not blinded to nasal spray contents at Scan 1, the participants were. Scan 2 followed a randomized, double-blind design. At scan 2, half received a second placebo dose while the other half received 24 III of intranasal oxytocin. We measured neural responses to these animations at baseline, as well as the change in neural activity induced by oxytocin. Oxytocin reduced activation in early visual cortex and dorsal-stream motion processing regions for the social > size contrast, indicating reduced activity related to social attention. Oxytocin also reduced endorsements that shapes were "friends" or "not friends," and this significantly correlated with reduction in neural activation. Furthermore, participants who perceived fewer social relationships at baseline were more likely to show oxytocin-induced increases in a broad network of regions involved in social perception and social cognition, suggesting that lower social processing at baseline may predict more positive neural responses to oxytocin.