Serum γ-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults.
Serum γ-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults.
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DOI：
10.1016/j.jceh.2012.10.004
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发表时间：
2013-03-01
影响因子：
3
通讯作者：
Barrett-Connor E
中科院分区：
文献类型：
--
作者：
Loomba R;Doycheva I;Bettencourt R;Cohen B;Wassel CL;Brenner D;Barrett-Connor E
血清γ谷氨酰转肽酶(GGT)是脂肪肝的一个标志，它可以预测年轻人的死亡率。然而，血清GGT与老年人死亡率之间的关系尚不清楚。检查血清GGT升高是否能预测社区老年人的全因、心血管(CVD)和肝脏死亡率。一项前瞻性队列研究包括2364名来自兰乔·贝尔纳多研究的参与者(平均年龄70岁，BMI-24.5 kg/m2，54%女性)，他们参加了1984-87年的一次研究访问，当时确定了包括血清GGT在内的多种代谢协变量。平均(±标准差)为13.7(±6.2)年。我们进行了多变量调整的COX比例风险分析，以检验血清GGT升高(男性为>；51U/L，女性为>；33U/L)与各种原因、心血管疾病和肝脏死亡率之间的关系。在这些老年男性和女性中，累积死亡率为56.2%(n=1329)，其中心血管疾病和肝脏死亡分别占总死亡人数的49.4%和2.3%，随访时间为32,387人年。经多因素分析(调整年龄、性别、饮酒、体重指数、总胆固醇、高密度脂蛋白胆固醇、血清甘油三酯、吸烟状况、收缩压、糖尿病、血清白介素6和C反应蛋白)，血清GGT升高与全因(HR，1.55，95%CI，1.21-1.98)、心血管疾病(HR，1.51，95%CI，1.04-2.17)和肝脏死亡率(HR，9.10，95%CI，3.42-24.26)显著相关。在社区老年人中，血清GGT是全因、心血管疾病和肝脏死亡率的独立预测因子。
Serum γ-glutamyltranspeptidase (GGT), a marker of fatty liver disease (FLD), predicts mortality in young adults. However, the association between serum GGT and mortality in older adults is unclear. To examine if elevated serum GGT predicts all-cause, cardiovascular (CVD), and liver mortality in community-dwelling older adults. A prospective cohort study including 2364 participants (mean-age 70 yr, BMI-24.5 kg/m2, 54% women) from the Rancho Bernardo Study who attended a research visit in 1984–87 when multiple metabolic covariates were ascertained including serum GGT. They were followed for a mean (± standard deviation) of 13.7 (±6.2) years. Multivariable-adjusted Cox-proportional hazards analyses were conducted to examine the association between elevated serum GGT (>51 U/L in men and > 33 U/L in women) and all-cause, CVD, and liver mortality. In these older men and women, cumulative mortality was 56.2% (n=1329) with CVD and liver mortality accounting for 49.4% and 2.3% of all deaths, respectively, over 32,387 person-years of follow-up. In multivariate analyses (adjusted for age, sex, alcohol use, body-mass-index, total cholesterol, HDL cholesterol, serum triglyceride, smoking status, systolic blood pressure, diabetes mellitus, serum interleukin-6, and c-reactive protein), serum GGT elevation was significantly associated with all-cause (HR, 1.55, 95% CI, 1.21–1.98), CVD (HR, 1.51, 95% CI, 1.04–2.17), and liver mortality (HR, 9.10, 95% CI, 3.42–24.26). In community-dwelling older adults, serum GGT is an independent predictor of all-cause, CVD, and liver mortality.