cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
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DOI：
10.1006/dbio.2000.9677
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发表时间：
2000-05-01
影响因子：
2.7
通讯作者：
Jarman, AP
中科院分区：
文献类型：
--
作者：
Goulding, SE;White, NM;Jarman, AP
在果蝇神经发生中，原神经基因编码神经前体选择所需的 bHLH 蛋白。但许多脊椎动物同源物的表达较晚，并被认为在神经发生过程中具有多种作用。我们分离出了一种新的果蝇基因 cato，它编码的蛋白质具有与原神经蛋白 Atonal 密切相关的 bHLH 结构域。 cato 表达仅限于发育中的 PNS，在前体选择和终末分化阶段之间表达（因此晚于原神经基因）。我们提供了功能丧失和错误表达实验的证据，表明卡托参与感觉神经元形态。此外，在prospero突变体中，轴突和树突生长有缺陷，cato在发育中的中枢神经系统中受到强烈抑制。 (C) 2000 年学术出版社。
In Drosophila neurogenesis, proneural genes encode bHLH proteins that are required for neural precursor selection. But many vertebrate homologues are expressed later and are postulated to have multiple roles during neurogenesis. We have isolated a new Drosophila gene, cato, which encodes a protein with a bHLH domain that is closely related to that of the proneural protein Atonal. cato expression is restricted to the developing PNS, where it is expressed in between the stages of precursor selection and terminal differentiation (and therefore later than the proneural genes). We present evidence from loss of-function and misexpression experiments that cato is involved in sensory neurone morphology. Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS. (C) 2000 Academic Press.