Emergence of fluoroquinolone-resistant tuberculosis in New York City.
Emergence of fluoroquinolone-resistant tuberculosis in New York City.
复制标题
纽约市出现耐氟喹诺酮结核病。
DOI：
10.1016/s0140-6736(95)90980-x
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Frieden,TR
中科院分区：
文献类型：
--
作者：
Sullivan,EA;Kreiswirth,BN;Palumbo,L;Kapur,V;Musser,JM;Ebrahimzadeh,A;Frieden,TR
22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.
