Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
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DOI：
10.1016/j.bbamcr.2015.11.005
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Metzger JM
中科院分区：
文献类型：
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作者：
Bedada FB;Wheelwright M;Metzger JM
由心肌梗死引起的人类心力衰竭是一个主要的健康问题。移植器官的缺乏限制了患病和衰竭的成人心脏的治疗方法。人诱导多能干细胞来源的心肌细胞(hiPSC-CMS)有可能提供一种长期的、可行的、再生的药物替代。在从HiPSCs高效生成心肌细胞方面已经取得了重大进展。然而，指导HiPSC-CMS获得类似于成熟心脏组织的生理结构、基因表达谱和功能仍然是一个主要障碍。因此，HiPSC-CMS在进入转化医学之前有几个障碍需要克服。在这次审查中，我们讨论了已经取得的进展、知识方面的空白和仍然存在的挑战。
Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative approaches for the diseased and failing adult heart. Human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) have the potential to provide a long-term, viable, regenerative-medicine alternative. Significant progress has been made with regard to efficient cardiac myocyte generation from hiPSCs. However, directing hiPSC-CMs to acquire the physiological structure, gene expression profile and function akin to mature cardiac tissue remains a major obstacle. Thus, hiPSC-CMs have several hurdles to overcome before they find their way into translational medicine. In this review, we address the progress that has been made, the void in knowledge and the challenges that remain.