Regulation of the pyruvate dehydrogenase complex.
Regulation of the pyruvate dehydrogenase complex.
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DOI：
10.1042/bst20060217
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发表时间：
2006-04
影响因子：
3.9
通讯作者：
M. Patel;L. Korotchkina
中科院分区：
文献类型：
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作者：
M. Patel;L. Korotchkina
丙酮酸脱氢酶复合体(PDC)在维持哺乳动物体内葡萄糖稳态中起着核心作用。通过PDC的碳通量受到翻译后(短期)磷酸化/去磷酸化和转录(长期)控制的复杂机制的精心控制。前者的调节机制涉及多个磷酸化位点和特定组织中专用的激酶和磷酸酶的分布，不仅依赖于复合体的催化和调节成分之间的相互作用，而且对线粒体内氧化还原状态和代谢物水平作为能量状态的指标也很敏感。此外，对PDC调节成分的差异转录控制进一步增加了长期调节PDC活性以维持正常和疾病状态下的葡萄糖平衡所需的复杂性。
The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. The former regulatory mechanism involving multiple phosphorylation sites and tissue-specific distribution of the dedicated kinases and phosphatases is not only dependent on the interactions among the catalytic and regulatory components of the complex but also sensitive to the intramitochondrial redox state and metabolite levels as indicators of the energy status. Furthermore, differential transcriptional controls of the regulatory components of PDC further add to the complexity needed for long-term tuning of PDC activity for the maintenance of glucose homoeostasis during normal and disease states.