Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis
Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis
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DOI：
10.1016/j.ajem.2019.10.023
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发表时间：
2020-03-01
影响因子：
3.6
通讯作者：
Huang, Kegang
中科院分区：
文献类型：
--
作者：
Huang, Zhiwei;Fu, Zhaoyin;Huang, Kegang
Background: Neutrophil-to-lymphocyte ratio (NLR) has been used to predict the prognosis of patients with sepsis with inconsistent results. This meta-analysis aimed to clarify the prognostic value of NLR in patients with sepsis.Methods: A comprehensive literature search for relevant studies, published prior to March 2019, was conducted using PubMed, Web of Science, and the China National Knowledge.Infrastructure database. Standard mean differences (SMDs) with 95% confidence intervals (CI) were used to evaluate the NLR of patients with sepsis retrospectively. Hazard ratios (HRs) with 95% CIs were used to evaluate the prognostic value of NLR in patients with sepsis.Results: Patients from 14 studies (n = 11,564) were selected for evaluation. Nine studies (1371 patients) analyzed the NLR in these patients. The pooled results showed significantly higher NLR in non-survivors than in survivors (random-effects model: SMD = 1.18, 95% CI; 0.42-1.94). Nine studies (10,685 patients) evaluated the prognostic value of NLR for sepsis; the pooled results showed that higher NLR was associated with poor prognosis in patients with sepsis (fixed-effects model: HR = 1.75, 95% CI; 1.56-1.97). Subgroup analysis revealed that study design, cut-off NLR, or primary outcome did not affect the prognostic value of NLR in patients with sepsis.Conclusion: This meta-analysis indicates that NLR may be a helpful prognostic biomarker of patients with sepsis and that higher NLR values may indicate unfavorable prognoses in these patients. (C) 2019 Elsevier Inc. All rights reserved.
