FBA Ecological Guild: Trio of Firmicutes-Bacteroidetes Alliance against Actinobacteria in Human Oral Microbiome
FBA Ecological Guild: Trio of Firmicutes-Bacteroidetes Alliance against Actinobacteria in Human Oral Microbiome
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DOI：
10.1038/s41598-019-56561-1
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发表时间：
2020-01-14
影响因子：
4.6
通讯作者：
Ma, Zhanshan (Sam)
中科院分区：
文献类型：
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作者：
Li, Wendy;Ma, Zhanshan (Sam)
在一项开创性的研究中，Zaura 等人。 （2009）发现大多数口腔微生物属于五个门，包括厚壁菌门、变形菌门、放线菌门、拟杆菌门和梭杆菌门。随后的研究进一步确定了一组在无关个体（即核心）之间常见的微生物。然而，这些现有的研究可能并不是为了调查各种核心物种之间的相互作用。在这里，通过利用生态网络分析的力量，我们以网络集群的形式识别了一些重要的生态行会。特别是，我们发现最强的集群是厚壁菌门和拟杆菌门针对放线菌的联盟（FBA-guild）。在该群内，我们进一步确定了两个亚群，即放线菌为主的亚群（ASG）和厚壁菌门为主的拟杆菌亚群（FBSG）。此外，我们在两个子行会中都识别出了所谓的守护节点，它们的作用可能是抑制对等子行会，因为它们只与外部节点进行竞争性交互，而只与内部节点进行合作性交互，我们将其称为平民节点，因为它们只进行合作性交互。我们推测 FBA 协会可能与保护口腔健康有关，以防止来自棒状杆菌和放线菌的一些机会性病原体，这两个放线菌属（FB 联盟的目标）的主要属。
In a pioneering study, Zaura et al. (2009) found that majority of oral microbes fall within the five phyla including, Firmicutes, Proteobacteria, Actinobacteria, Bacteroidetes and Fusobacteria. Subsequent studies further identified a set of microbes that were commonly shared among unrelated individuals (i.e., core). However, these existing studies may have not been designed to investigate the interactions among various core species. Here by harnessing the power of ecological network analysis, we identified some important ecological guilds in the form of network clusters. In particular, we found that the strongest cluster is an alliance between Firmicutes and Bacteroidetes against Actinobacteria (FBA-guild). Within the guild, we further identified two sub-guilds, the Actinobacteria-dominant sub-guild (ASG) and Firmicutes-dominant allied with Bacteroidetes sub-guild (FBSG). Furthermore, we identified so-termed guard nodes in both sub-guilds, and their role may be to inhibit the peer sub-guild given they held competitive interactions only with the outside nodes only but held cooperative interactions only with the internal nodes, which we termed civilian nodes given that they only held cooperative interactions. We postulated that FBA-guild might be to do with protection of oral health against some opportunistic pathogens from Corynebacterium and Actinomyces, the two major genera of Actinobacteria (target of FB alliance).