Bacterial membrane lipids in the action of antimicrobial agents
Bacterial membrane lipids in the action of antimicrobial agents
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DOI：
10.1002/psc.1319
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发表时间：
2011-05-01
影响因子：
2.1
通讯作者：
Epand, Raquel F.
中科院分区：
文献类型：
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作者：
Epand, Richard M.;Epand, Raquel F.
许多靶向细菌的抗微生物剂是阳离子的，并且可以与暴露在细菌膜上的阴离子脂质组分相互作用。细菌在细胞膜中的主要脂质成分的性质上差异很大。那些既具有阴离子又具有两性离子或中性脂质的细菌可以在具有几个阳离子电荷的抗微生物肽的存在下被诱导形成结构域。这种阴离子和两性离子脂质分离到结构域中可导致细胞生长停滞或细胞死亡。这些试剂通常对革兰氏阴性菌比革兰氏阳性菌更具毒性。这些发现强调了细菌膜的脂质组成在确定生物体对某些抗菌剂作用的敏感性方面的重要性。版权所有（C）2010欧洲肽协会和约翰威利父子有限公司。
Many antimicrobial agents that target bacteria are cationic and can interact with the anionic lipid components that are exposed on the bacterial membrane. Bacteria vary widely in the nature of the major lipid components that are in the cell membrane. Those bacteria with both anionic as well as zwitterionic or neutral lipids can be induced to form domains in the presence of antimicrobial peptides possessing several cationic charges. This segregation of anionic and zwitterionic lipids into domains can result in the arrest of cell growth or in cell death. Such agents are generally more toxic to Gram-negative bacteria, than to Gram-positive ones. These findings emphasize the importance of the lipid composition of bacterial membranes in determining the susceptibility of the organism to the action of certain antimicrobial agents. Copyright (C) 2010 European Peptide Society and John Wiley & Sons, Ltd.