New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12
New dihydronaphthothiophene derivatives by the biological transformation of seriniquinone using marine-derived actinomycete Streptomyces albogriseolus OM27-12
复制标题
利用海洋来源的放线菌 Streptomyces albogriseolus OM27-12 对丝氨酸醌进行生物转化，得到新的二氢萘并噻吩衍生物
DOI：
10.1038/s41429-021-00484-5
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Fukuda Takashi
中科院分区：
文献类型：
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作者：
Ishida Kohei;Tanaka Teruki;Nagai Kenichiro;Furuichi Yoshimasa;Terahara Takeshi;Ando Masashi;Tsukamasa Yasuyuki;Fukuda Takashi
丝氨醌最初是作为一种黑色素瘤选择性抗癌剂从海洋细菌的培养液中分离出来的。目前正在对其选择性和独特靶点进行药理学研究。利用海洋放线菌StreptomycesalbogriseolusOM 27 -12生物转化丝氨醌，合成了一个新的二氢萘并噻喃酮（1），并对其衍生物（2-4）进行了化学合成。化合物1 - 4对黑色素瘤具有选择性细胞毒活性，并改善了溶解性。
Seriniquinone was originally isolated as a melanoma-selective anti-cancer agent from a culture broth of marine bacteria. Pharmacological studies on its selectivity and unique target are ongoing. A new dihydronaphthothiophene (1) was synthesized by the biological transformation of seriniquinone using marine-derived actinomyceteStreptomyces albogriseolusOM27-12, and its derivatives (2–4) were chemically synthesized. Compounds1–4exhibited selective cytotoxic activity against melanoma and improved solubility.