Sleep duration and hypercholesterolaemia: Results from the National Health Interview Survey 2008.
Sleep duration and hypercholesterolaemia: Results from the National Health Interview Survey 2008.
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DOI：
10.1016/j.sleep.2011.07.017
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发表时间：
2012-02
期刊：
影响因子：
4.8
通讯作者：
Shankar, Anoop
中科院分区：
文献类型：
--
作者：
Sabanayagam, Charumathi;Shankar, Anoop
先前的研究表明，睡眠时间与高胆固醇血症之间存在不一致的联系。这项研究调查了美国成年人中具有全国代表性的睡眠时间和高胆固醇血症之间的关系。对2008年全国健康访谈调查的16,652名参与者（年龄≥18岁，52.5%为女性）进行了横断面研究。睡眠时间分为≤5、6、7、8或≥9小时。通过问卷调查评估高胆固醇血症（n=5578）。睡眠时间与高胆固醇血症之间存在显著的性别差异（P交互作用=0.0003）。在女性中，在调整了体力活动、心理困扰、体重指数、糖尿病和高血压等潜在混杂因素和介质后，睡眠时间≤5小时与高胆固醇血症呈正相关。与睡眠时间为7小时（参照）相比，睡眠时间≤5小时的高胆固醇血症的多因素优势比（OR）为1.27[95%可信区间（CI） 1.04-1.54]。相反，在男性中，睡眠时间≥8小时与高胆固醇血症呈负相关。与睡眠时间为7小时（参照）相比，睡眠时间为8小时和≥9小时的高胆固醇血症的多变量OR分别为0.80 （95% CI 0.69-0.94）和0.78 （95% CI 0.60-1.00）。在亚组分析中，睡眠时间≤5小时与女性高胆固醇血症呈正相关，睡眠时间≤8小时与男性高胆固醇血症负相关在年龄<60岁和非西班牙裔白人以外的种族/族裔群体中更为明显。女性睡眠时间≤5小时与高胆固醇血症呈正相关，而男性睡眠时间≥8小时与高胆固醇血症呈负相关。
Previous studies have shown an inconsistent association between sleep duration and hypercholesterolaemia. This study examined the association between sleep duration and hypercholesterolaemia in a nationally representative sample of US adults. A cross-sectional study of 16,652 participants in the 2008 National Health Interview Survey (aged ≥18 years, 52.5% women) was conducted. Sleep duration was categorized as ≤5, 6, 7, 8 or ≥9 h. Hypercholesterolaemia (n=5578) was assessed by questionnaire. A significant gender difference was found in the association between sleep duration and hypercholesterolaemia (P interaction=0.0003). Among women, sleep duration ≤5 h was positively associated with hypercholesterolaemia after adjusting for potential confounders and mediators including physical activity, psychological distress, body mass index, diabetes mellitus and hypertension. Compared with a sleep duration of 7 h (referent), the multivariate odds ratio (OR) of hypercholesterolaemia was 1.27 [95% confidence interval (CI) 1.04–1.54] for sleep duration ≤5 h. In contrast, among men, sleep duration ≥8 h was inversely associated with hypercholesterolaemia. Compared with a sleep duration of 7 h (referent), the multivariate OR of hypercholesterolaemia was 0.80 (95% CI 0.69–0.94) and 0.78 (95% CI 0.60–1.00) for sleep durations of 8 and ≥9 h, respectively. In subgroup analyses, the positive association between sleep duration ≤5 h and hypercholesterolaemia in women, and the inverse association between sleep duration ≤8 h and hypercholesterolaemia in men were more pronounced among those aged <60 years and race/ethnic groups other than non-Hispanic Whites. Sleep duration ≤5 h was positively associated with hypercholesterolaemia in women, whereas sleep duration ≥8 h was inversely associated with hypercholesterolaemia in men.
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