Phenotyping women with detrusor underactivity by presumed etiology: Is it plausible?
Phenotyping women with detrusor underactivity by presumed etiology: Is it plausible?
复制标题
通过推测的病因对逼尿肌活动不足的女性进行表型分析：这合理吗？
DOI：
10.1002/nau.23079
复制
发表时间：
2017
影响因子：
2
通讯作者：
Reynolds,WilliamS
中科院分区：
文献类型：
--
作者：
Brown,ElizabethT;Cohn,JoshuaA;Kaufman,MelissaR;Dmochowski,RogerR;Reynolds,WilliamS
目的膀胱活动不足(UAB)是一种病因不明的症状复合体。这项研究的目的是确定临床和UDS参数在假定的逼尿肌活动不足(DU)病因类别之间是否存在差异。方法从2011年到2015年在一家机构进行回顾性回顾，以确定有UAB症状的患者。如果患者是男性，有抗尿失禁，或在1年内接受了盆腔器官脱垂(POP)手术，或者UDS没有显示出符合定义的DU，则排除这些患者。受试者按病因学分为四组：心血管疾病表现(CV)、心脏危险因素(CVR)、神经病学(N)或特发性(I)。结果符合纳入标准的2 0 0例患者中，N = 5 3例(2 6.5%)，N = 44例[2 2%]，N：N = 81例[40.5%]，I：N = 2 2例[11%]。简历队列中的女性年龄明显较大，且更有可能是绝经后(P<； 0.001)。体重指数(P= 0.48)、反复尿路感染(P= 0.6 3)、尿潴留病史(P= 0.6 5)、POP(0.49)、美国泌尿外科协会症状评分(AUA-SS)(P= 0.0 6)、出现症状[紧迫性、频度、急迫性尿失禁、AUR、排空不全、犹豫不决、尿路感染(P= 0.97)]、UDS参数(首次感觉[P= 0.2 5]、欲望正常[P= 0.80]、强烈欲望[P= 0.58])在队列间差异无统计学意义。容量[P= 0.11]，最大尿流率[P= 0.5 0]，最大尿流率[P= 0.2 2]，排尿后残留量[P= 0.82]。结论虽然年龄和绝经状况在队列之间存在差异，但临床和尿动力学参数在假定的病因类别中并未显示出明显的差异，提示DU的病因可能是多因素的。乌罗代南。2017年36：1151-1154。©2016 Wiley期刊，Inc.
AimsUnderactive bladder (UAB) is a symptom complex with poorly characterized causation. The aim of this study was to determine if clinical and UDS parameters differed between categories of presumed detrusor underactivity (DU) etiologies.MethodsA retrospective review was performed at a single institution from 2011 to 2015 to identify patients with symptoms of UAB. Patients were excluded if they were male, had anti‐incontinence, or pelvic organ prolapse (POP) surgery within 1 year, or the UDS did not demonstrate DU as defined within. Subjects were stratified by etiology into four cohorts: cardiovascular disease manifestations (CV), cardiac risk factors (CVR), neurologic (N), or idiopathic (I). Patient demographics, comorbidities, symptomatology, physical exam, and UDS parameters were compared.ResultsA total of 200 patients met inclusion criteria (CV: n = 53 [26.5%], CVR: n = 44 [22%] N: n = 81 [40.5%], I: n = 22 [11%]). Women in the CV cohort were significantly older and more likely to be post‐menopausal (P< 0.001). There were no differences between cohorts for BMI (P= 0.48), recurrent UTI (P= 0.63), history of urinary retention (AUR) (P= 0.65), POP (0.49), American Urological Association Symptom Score (AUA‐SS) (P= 0.06), presenting symptomatology [urgency, frequency, urgency urinary incontinence, AUR, incomplete emptying, hesitancy, UTI (P= 0.97)], or UDS parameters (first sensation [P= 0.25], normal desire [P= 0.80], strong desire [P= 0.58], capacity [P= 0.11], Qmax[P= 0.50], Pdetat Qmax[P= 0.22], post‐void residual [P= 0.82]).ConclusionsThough differences were observed between cohorts for age and menopausal status, clinical or urodynamic parameters did not demonstrate distinct differences across presumed categories of etiology, suggesting that the etiology of DU may be multifactorial.Neurourol. Urodynam. 36:1151–1154, 2017. © 2016 Wiley Periodicals, Inc.