Predictive factors for poor peripheral blood stem cell mobilization and peak CD34+ cell count to guide pre-emptive or immediate rescue mobilization
Predictive factors for poor peripheral blood stem cell mobilization and peak CD34+ cell count to guide pre-emptive or immediate rescue mobilization
复制标题
DOI：
10.3109/14653249.2012.681042
复制
发表时间：
2012-08-01
期刊：
影响因子：
4.5
通讯作者：
Ribera, Josep-Maria
中科院分区：
文献类型：
--
作者：
Sancho, Juan-Manuel;Morgades, Mireia;Ribera, Josep-Maria
背景目标。外周血（PB）干细胞动员失败是不进行造血干细胞移植（HSCT）的常见原因。及早识别不良动员者可以避免重复尝试动员，并进行先发制人的救援动员。方法。收集了 2000 年至 2010 年间连续转诊进行自体 HSCT 的 397 名患者的首次动员计划的数据。动员不良定义为13.8/μL的收集足以确保> = 2 x 10(6) CD34(+)细胞/kg，具有高灵敏度(90%)和特异性(91%)。结论。活动不良的发生率很高，与疾病类型、嘌呤类似物治疗和多种化疗方案有关。 PB 中 CD34(+) 细胞计数的阈值识别出较差的动员者，其中立即或先发制人的普乐沙福给药可能有助于避免第二次动员。
Background aims. Failure in mobilization of peripheral blood (PB) stem cells is a frequent reason for not performing hematopoietic stem cell transplantation (HSCT). Early identification of poor mobilizers could avoid repeated attempts at mobilization, with the administration of pre-emptive rescue mobilization. Methods. Data from the first mobilization schedule of 397 patients referred consecutively for autologous HSCT between 2000 and 2010 were collected. Poor mobilization was defined as the collection of 13.8/mu L was enough to ensure >= 2 x 10(6) CD34(+) cells/kg, with high sensitivity (90%) and specificity (91%). Conclusions. The prevalence of poor mobilization was high, being associated with disease type, therapy with purine analogs and multiple chemotherapy regimens. The threshold of CD34(+) cell count in PB identified poor mobilizers, in whom the administration of immediate or pre-emptive plerixafor could be useful to avoid a second mobilization.