A new view of the so-called adenoma malignum of the uterine cervix
A new view of the so-called adenoma malignum of the uterine cervix
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DOI：
10.1007/s004280050172
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发表时间：
1998-04-01
期刊：
影响因子：
3.5
通讯作者：
Katsuyama, T
中科院分区：
文献类型：
--
作者：
Ishii, K;Hosaka, N;Katsuyama, T
子宫颈粘液性腺瘤（粘液型微偏腺癌，粘液性MDA）是一种独特的肿瘤，由于肿瘤细胞的良性外观而难以诊断。本研究旨在探讨这种肿瘤的表型表达与非肿瘤性宫颈组织和各种类型的宫颈癌相比。应用胃粘液、胃蛋白酶原、溶菌酶、嗜铬粒蛋白A和癌胚抗原等多种组织化学染色方法，对10例粘液性MDA、50例非肿瘤性宫颈组织、13例宫颈腺癌（包括宫颈管型或肠型）和粘液样腺癌、2例粘液表皮样癌进行了检测。结果表明，粘液MDA特征性地表现出胃表型。9例粘液性MDA和5例其他检查病例中也发现胃上皮化生。7例宫颈型腺癌中有4例表现为胃表型，3例宫颈型腺癌中有2例表现为相同的局部特征。这些结果表明，在子宫颈中存在一组表达胃表型的病变，并表明这些病变之间的密切关系。表达胃表型的宫颈腺癌可能来源于MDA。
Adenoma malignum of the uterine cervix (mucinous type of minimal deviation adenocarcinoma, mucinous MDA), is a unique neoplasm that is difficult to diagnose owing to the deceptively benign appearance of the tumour cells. The present study was undertaken to explore the phenotypic expression of this tumour compared with those of non-neoplastic cervical tissues and of cervical carcinomas of various types. Ten cases of mucinous MDA, 50 cases with non-neoplastic cervical tissues, 13 of cervical adenocarcinoma including the mucinous (endocervical or intestinal type) and endometrioid types, and 2 of mucoepidermoid carcinoma were examined by various histochemical staining methods, including those for gastric mucins, pepsinogen, lysozyme, chromogranin A and carcinoembryonic antigen. The results revealed that mucinous MDA characteristically exhibited gastric phenotypes. The presence of gastric metaplasia was also demonstrated in 9 cases of mucinous MDA and in 5 of the other cases examined. The 7 endocervical-type adenocarcinomas also included 4 that expressed gastric phenotypes, and 2 of the 3 intestinal-type adenocarcinomas showed the same properties focally. These results indicate the presence of a group of lesions expressing gastric phenotypes in the uterine cervix and suggest a close relationship between these lesions. Cervical adenocarcinomas expressing gastric phenotypes are probably derived from MDA.