A mathematical modeling toolbox for ion channels and transporters across cell membranes
A mathematical modeling toolbox for ion channels and transporters across cell membranes
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DOI：
10.1016/j.ijheatmasstransfer.2021.121423
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发表时间：
2021-06-09
影响因子：
5.2
通讯作者：
Hassanipour，Fatemeh
中科院分区：
文献类型：
--
作者：
Zaheri，Shadi;Hassanipour，Fatemeh
膜转运蛋白和离子通道的数学模型有助于研究人员全面了解膜转运蛋白之间的复杂调节过程，估计其机制的变化和不确定性，并研究这些过程中的紊乱如何可能导致疾病。包含大多数可用的离子通道和转运蛋白模型的统一数学框架可以帮助科学家更方便地选择合适的模型。在这方面，这项工作提出了一套全面的、最新的当前可用的数学方程，用于模拟离子通道和膜转运蛋白机制。本文旨在提供一个数学框架，用于模拟分子通过膜转运蛋白和离子通道在细胞内的转运，例如营养物、无机离子、药物和毒素。我们的目的是大大节省寻找适用于不同类别膜转运蛋白的数学模型所需的时间和资源，并改善对该领域感兴趣的不同背景的科学家之间的交流。
Mathematical modeling of membrane transporters and ion channels helps researchers obtain a thorough understanding of the complex regulation process between membrane transporters, estimate the changes and uncertainties of their mechanisms, and study how disorders in these procedures may cause disease. A unified mathematical framework that includes most available models for ion channels and transporters can help scientists choose the appropriate model more conveniently. In this regard, this work presents a comprehensive, up-to-date set of currently available mathematical equations for modeling ion channel and membrane transporter mechanisms. This paper aims to provide a mathematical framework for modeling molecule transport, such as nutrients, inorganic ions, drugs, and toxins, across the cell through membrane transporters and ion channels. Our purpose is to substantially save the time and resources needed to find the mathematical models available for different classes of membrane transporters and improve communication between scientists with different backgrounds interested in this field.