The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer
The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer
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NF-κB 调节的 miR-194-5p/IGF1R/PPFIBP 轴对于卵巢癌的肿瘤发生至关重要
DOI：
10.7150/jca.40604
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Sun, Jianmin
中科院分区：
文献类型：
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作者：
Bai, Ru;Dou, Kaikai;Sun, Jianmin
miRNA 参与多种恶性肿瘤的发生。在本研究中，我们发现卵巢癌组织中miR-194-5p表达下调，miR-194-5p表达下调促进人卵巢癌细胞体外增殖、侵袭和迁移以及裸鼠卵巢肿瘤生长。我们进一步发现IGF1R和PPFIBP是miR-194-5p的靶标，miR-194-5p表达下调会增加IGF1R和PPFIBP表达，导致卵巢癌细胞增殖、侵袭和迁移增加。此外，我们发现NF-κB可以与miR-194-5p的启动子区域结合，并负向调节卵巢癌细胞中miR-194-5p的表达。综上所述，我们的结果表明 NF-κB 调节的 miR-194-5p/IGF1R/PPFIBP 轴对于卵巢癌的肿瘤发生至关重要，这为卵巢癌的发展提供了新的见解。
miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promoter region of miR-194-5p, and negatively regulate the expression of miR-194-5p in ovarian cancer cells. Taken together, our results suggested a NF-κB modulated miR-194-5p/IGF1R/ PPFIBP axis that is crucial for the tumorigenesis of ovarian cancer, which provides a new insight into the development of ovarian cancer.