A New Variant of 16S rRNA Methylase, RmtD3, in a Clinical Isolate of Pseudomonas aeruginosa in Myanmar
A New Variant of 16S rRNA Methylase, RmtD3, in a Clinical Isolate of Pseudomonas aeruginosa in Myanmar
复制标题
缅甸铜绿假单胞菌临床分离株中的 16S rRNA 甲基化酶新变体 RmtD3
DOI：
10.1128/aac.01806-17
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发表时间：
2017
影响因子：
4.9
通讯作者：
Tin Htay Htay
中科院分区：
文献类型：
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作者：
Tada Tatsuya;Shimada Kayo;Mya San;Zan Khin Nyein;Kuwahara Kyoko;Kirikae Teruo;Tin Htay Htay
获得性16S rRNA甲基酶导致革兰氏阴性病原菌对各种氨基糖苷类抗生素产生极高水平的耐药性，包括肠杆菌科细菌和葡萄糖非发酵菌(1)。到目前为止，已在临床分离株中发现了10种16S rRNA甲基酶，包括ArmA、RmtA、RmtB、RmtC、RmtD、RmtE、RmtF、RmtG、RmtH和NPMA。其中一种名为RmtD，于2005年在巴西一名住院患者的铜绿假单胞菌临床分离株中首次检测到(6)。随后，在7株临床分离株中发现了RmtD2，RmtD的变异体
Acquired 16S rRNA methylases are responsible for an extremely high level of resistance against various aminoglycosides in Gram-negative pathogens, including Enterobacteriaceae and glucose-nonfermentative bacteria (1). To date, 10 kinds of 16S rRNA methylases, including ArmA, RmtA, RmtB, RmtC, RmtD, RmtE, RmtF, RmtG, RmtH, and NpmA, have been found in clinical isolates (2–5). One of these, RmtD, was first detected in a clinical isolate of Pseudomonas aeruginosa from an inpatient in 2005 in Brazil (6). Subsequently, RmtD2, a variant of RmtD, was found in 7 clinical isolates of