Temporal dynamics of basal ganglia response and connectivity during verbal working memory
Temporal dynamics of basal ganglia response and connectivity during verbal working memory
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DOI：
10.1016/j.neuroimage.2006.08.056
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发表时间：
2007-02-01
期刊：
影响因子：
5.7
通讯作者：
Menon, Vinod
中科院分区：
文献类型：
--
作者：
Chang, Catherine;Crottaz-Herbette, Sonia;Menon, Vinod
关于工作记忆的神经基础的研究一般集中在新皮层区域，而对皮层下结构的作用知之甚少。越来越多的证据表明基底神经节参与了WM，但它们对WM不同组成过程的贡献却知之甚少。我们研究了基底神经节反应和连接的时间动态。斯滕贝格工作记忆任务的编码、维持和反应阶段。在编码和维持阶段，WM负载依赖性激活观察到在左前尾状核，前壳核和苍白球;激活在右前尾状核只观察到在维持阶段。在反应阶段，基底神经节在高负荷和低负荷WM条件下同样活跃。尾状核和壳核激活主要定位于基底神经节的（喙）关联部分，与这些区域在认知处理中的假定作用一致。有效的连接分析显示，在任务的所有三个阶段，左前尾状核与左后顶叶皮层的WM负荷依赖性相互作用增加;与视觉联想皮层，包括梭状回和颞下回，仅在编码阶段;与腹外侧前额叶皮层在编码和维持阶段;在维持和反应阶段与前辅助运动区;仅在反应阶段与背外侧前额叶和前扣带皮层。与已知的基底神经节的神经解剖学，这些结果表明，前尾状核有助于链接在不同的功能网络中的信号在不同阶段的WM任务。我们的研究为基底神经节在高级认知功能中的整合和适应作用提供了新的见解。(c)2006年爱思唯尔公司All rights reserved.
Research on the neural basis of working memory (WM) has generally focused on neocortical regions; comparatively little is known about the role of subcortical structures. There is growing evidence that the basal ganglia are involved in WM, but their contribution to different component processes of WM is poorly understood. We examined the temporal dynamics of basal ganglia response and connectivity during the. encoding, maintenance and response phases of a Sternberg WM task. During the encoding and maintenance phases, WM-load-dependent activation was observed in the left anterior caudate, anterior putamen and globus pallidus; activation in the right anterior caudate was observed only during the maintenance phase. During the response phase, the basal ganglia were equally active in both the high-load and low-load WM conditions. Caudate and putamen activations were primarily localized to the (rostral) associative parts of the basal ganglia, consistent with the putative role of these regions in cognitive processing. Effective connectivity analyses revealed increased WM-load-dependent interaction of the left anterior caudate with the left posterior parietal cortex during all three phases of the task; with the visual association cortex, including the fusiform gyrus and inferior temporal gyrus, only during the encoding phase; with the ventrolateral prefrontal cortex during the encoding and maintenance phases; with the pre-supplementary motor area during the maintenance and response phases; and with the dorsolateral prefrontal and anterior cingulate cortices only during the response phase. Taken together with known neuroanatomy of the basal ganglia, these results suggest that the anterior caudate helps to link signals in distinct functional networks during different phases of the WM task. Our study offers new insight into the integrative and adaptive role of the basal ganglia in higher cognitive function. (c) 2006 Elsevier Inc. All rights reserved.