Lateral habenula and hippocampus: a complex interaction raphe cells-mediated
Lateral habenula and hippocampus: a complex interaction raphe cells-mediated
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DOI：
10.1007/bf01291880
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发表时间：
1997-01-01
影响因子：
3.3
通讯作者：
LaGrutta, V
中科院分区：
文献类型：
--
作者：
Ferraro, G;Montalbano, ME;LaGrutta, V
研究表明，外侧缰核（LH）对海马锥体细胞有兴奋作用。调制的影响是自相矛盾的马槟榔碱介导的，事实上，所有LH刺激的影响被取消海马内离子电渗methysergide应用。结果提示中缝背核参与了脊髓损伤。事实上，电刺激中缝背核对海马产生了预期的抑制作用，海马内应用离子导入麦角新碱可以拮抗这种抑制作用。在这种神经结构的背景下，我们强调了两种类型细胞之间的去抑制关系：慢血清素能传出神经元和快GABA能中间神经元。对慢速和快速中缝细胞进行的以下实验测试也支持去抑制假说：a）低频和高频LH刺激; B）NMDA和GABA的离子电渗给药; c）2-APV（NMDA拮抗剂）和荷包牡丹碱（GABA拮抗剂）在缝内离子电渗注射期间的LH刺激。
The study has shown an excitatory influence exerted by lateral habenula (LH) on hippocampal pyramidal cells. The modulatory influence is paradoxically serotonine-mediated; in fact all LH stimulation effects were abolished by intrahippocampal iontophoretic methysergide application. The data suggest the involvement of dorsal raphe nucleus. In fact, the dorsal raphe nucleus stimulation caused on hippocampus an expected inhibitory effect antagonized by intrahippocampal iontophoretic methysergide application. In the context of this neural structure we have highlighted a disinhibitory relation between two types of cells: slow serotonergic efferent neurones and fast GABAergic interneurones. The disinhibitory hypothesis is also supported by the following experimental tests performed on both slow and fast raphe cells: a) LH stimulation at low and high frequencies; b) iontophoretic administration of NMDA and GABA; c) LH stimulation during intraraphe iontophoretic injection of 2-APV (NMDA antagonist) and bicuculline (GABA antagonist).