Differential regulation of Dlx gene expression by a BMP morphogenetic gradient.
Differential regulation of Dlx gene expression by a BMP morphogenetic gradient.
复制标题
DOI：
10.1387/ijdb.11461005
复制
发表时间：
2001-06
期刊：
影响因子：
--
通讯作者：
T. Luo;M. Matsuo‐Takasaki;J. Lim;T. Sargent
中科院分区：
文献类型：
--
作者：
T. Luo;M. Matsuo‐Takasaki;J. Lim;T. Sargent
Three members of the vertebrate Distal-less gene family, Dlx3, 5 and 6, are transcribed in early gastrula embryos of Xenopus laevis. This expression is confined to ectoderm and is excluded from the presumptive neural plate region. Expression of all three genes is dependent upon BMP signaling, with significant differences in how the three genes respond to the BMP antagonist chordin. This correlates with the different expression domain boundaries in vivo for Dlx3 compared to Dlx5 and 6, suggesting that BMP signal attenuation could be the primary factor in determining these different patterns in the gastrula ectoderm.
