High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.
High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.
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DOI：
10.5402/2011/707206
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Horn PS
中科院分区：
文献类型：
--
作者：
Morrison JA;Glueck CJ;Daniels SR;Wang P;Stroop DM;Horn PS
Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24–26 (partial R 2 = 12.3% P < .0001, 6.6% P = .0012). Changes in BMI and triglyceride (partial R 2 = 8.5% P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.
