Terminal differentiation of bone marrow NK cells and increased circulation of TIGIT+ NK cells may be related to poor outcome in acute myeloid leukemia
Terminal differentiation of bone marrow NK cells and increased circulation of TIGIT+ NK cells may be related to poor outcome in acute myeloid leukemia
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DOI：
10.1111/ajco.13723
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Xiangbo Zeng;Danlin Yao;Lian Liu;Yikai Zhang;Jing Lai;Jun Zhong;Xianfeng Zha;Yuhong Lu;Zhenyi Jin;Shaohua Chen;Yangqiu Li;Ling Xu
中科院分区：
文献类型：
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作者：
Xiangbo Zeng;Danlin Yao;Lian Liu;Yikai Zhang;Jing Lai;Jun Zhong;Xianfeng Zha;Yuhong Lu;Zhenyi Jin;Shaohua Chen;Yangqiu Li;Ling Xu
为进一步了解急性髓系白血病(AML)自然杀伤细胞(NK)功能障碍的特点，本研究分析了NK细胞亚群的分布、抑制性受体免疫球蛋白及其ITIM结构域(TIGIT)、杀伤细胞凝集素样受体(KLRG1)和成熟标志CD57在NK细胞亚群中的表达及其与患者预后的关系。
In order to further understand the feature of natural killer cell (NK) dysfunction in acute myeloid leukemia (AML), The distribution of NK cell subset the expression of the inhibitory receptors immunoglobulin and ITIM domain (TIGIT), killer cell lectin‐like receptor (KLRG1), and the expression of maturation marker CD57 in NK cell subsets and their correlation with patient outcomes were analyzed in this study.