Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3.
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3.
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DOI：
10.2147/ijn.s50070
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发表时间：
2013
影响因子：
8
通讯作者：
Galdiero M
中科院分区：
文献类型：
--
作者：
Gaikwad S;Ingle A;Gade A;Rai M;Falanga A;Incoronato N;Russo L;Galdiero S;Galdiero M
由于银纳米颗粒的潜在抗病毒活性，这些颗粒和病毒之间的相互作用吸引了极大的兴趣，并且是治疗传染病的许多研究努力的主题。在这项工作中，我们证明了银纳米粒子与单纯疱疹病毒1型和2型以及与人副流感病毒3型发生大小依赖性相互作用。我们表明，从不同的真菌生产银纳米粒子是可行的，其抗病毒活性取决于所使用的生产系统。银纳米颗粒能够降低病毒感染性，可能是通过阻断病毒与细胞的相互作用，这可能取决于银纳米颗粒的大小和zeta电位。较小尺寸的纳米颗粒能够抑制所分析病毒的感染性。
The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed.