Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells.
Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells.
复制标题
CD4 T 细胞响应黑色素瘤细胞的抗原呈递而产生细胞因子。
DOI：
10.1097/00008390-199904000-00010
复制
发表时间：
1999
影响因子：
2.2
通讯作者：
Lee,JS
中科院分区：
文献类型：
--
作者：
Brady,MS;Eckels,DD;Lee,F;Ree,SY;Lee,JS
Melanoma cells are unusual because, unlike most epithelial tumours, constitutive expression of HLA class II antigens Is common. We have previously demonstrated that a peptide-specific CD4+ T-cell clone proliferates briskly in response to peptide and HLA class II expressing melanoma cell lines derived from metastases. Here we demonstrate that these CD4+ T-cells secrete large amounts of Interferon-[gamma](IFN [gamma]) and interleukin-10 (IL10), and insignificant quantities of IL2 or IL4, In response to peptide presentation by both melanoma and autologous B-cells. T-cells produced more IL10 when responding to peptide presentation by melanoma cells compared with B-cells, and less IFN [gamma](P< 0.01). Addition of IL12 did not alter the cytokines produced but increased the T-cell production of both, especially the production of IL10 in response to peptide presentation by melanoma cells. Our data suggest that differential cytokine production by CD4+ T-cells in response to peptide presentation by HLA class II expressing tumour cells may contribute to tolerance to tumour antigens.
