Experimental Study of Speed-dependent Positional Nystagmus in Benign Paroxysmal Positional Vertigo
Experimental Study of Speed-dependent Positional Nystagmus in Benign Paroxysmal Positional Vertigo
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DOI：
10.1080/00016480310015010
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发表时间：
2003-06
影响因子：
1.4
通讯作者：
M. Furuya;Mamoru Suzuki;Harushiro Sato
中科院分区：
文献类型：
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作者：
M. Furuya;Mamoru Suzuki;Harushiro Sato
良性阵发性位置性眩晕（BPPV）的临床特点之一是头位改变越快，眩晕越严重。这表明，头部变化的速度是决定眩晕的发生和严重程度的关键。本研究的目的是探讨因素决定的症状BPPV使用模型的管结石和壶腹结石。材料和方法：采用牛蛙后半规管（PSC）制备管结石和壶腹结石模型。比较壶腹神经放电之间的快速和缓慢的位置变化，以检查决定BPPV症状的因素。结果：在泪小管结石模型中，由于位置变化快，耳石形成的加速度较大。这导致放电量更大，持续时间更长。随着位置的缓慢变化，放电变小、变短。在壶腹结石模型中，放电持续，其幅度在快速和缓慢的位置变化之间没有差异。胆管结石模型影响PSC的放电幅度取决于位置变化的速度。结论：胆管结石是BPPV更可能的机制，其特征是在运动位置改变时出现不同程度的眩晕。
Objective—One of the clinical characteristics of benign paroxysmal positional vertigo (BPPV) is that the more quickly the head position changes, the more severe the vertigo. This suggests that the velocity of the head change is critical in determining the occurrence and severity of vertigo. The aim of this study was to examine factors determining the symptoms of BPPV using models of canalolithiasis and cupulolithiasis. Material and Methods—Canalolithiasis and cupulolithiasis models were prepared using the bullfrog posterior semicircular canal (PSC). The ampullary nerve discharges were compared between quick and slow positional changes to examine factors determining the symptoms of BPPV. Results—In the canalolithiasis model, the acceleration of the otoconia was greater for the quick positional change. This resulted in a greater discharge with a longer duration. With the slow positional change, the discharges were smaller and shorter. In the cupulolithiasis model, the discharges were sustained and their magnitude did not differ between the quick and slow positional changes. The canalolithiasis model influenced the magnitude of discharge of the PSC depending on the speed of the positional change. Conclusions—Canalolithiasis is the more likely mechanism of BPPV, which is characterized by various degrees of vertigo upon kinetic positional change.